Component
CYP2A6 variant alleles in the 1995 coumarin phenotyping study; original nomenclature retained
CYP2A6 variant alleles in the 1995 coumarin phenotyping study; original nomenclature retained. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
CYP2A6 variant alleles were identified in individuals with poor coumarin metabolism, including a single-amino-acid inactivating variant.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/coumarin-research/7668294.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "aeb377e6bbda1a552066c5d1caf1bf558753096627b863835637a0f2f942b3b1", "start_char": 0, "end_char": 1316, "text_sha256": "aeb377e6bbda1a552066c5d1caf1bf558753096627b863835637a0f2f942b3b1"}
- experimental_model
- CYP2A gene sequencing and coumarin metabolic phenotyping
- exposure
- Original CYP2A6v1/v2 nomenclature; poor-metabolizer individuals
- limitations
- Historical variant labels retained; no automatic mapping to modern star alleles and no demonstrated prediction of liver injury.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human
- plain_language
- Inherited enzyme differences can change how coumarin is processed.
- primary_references
- [coumarin-p7668294] A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (1995). https://pubmed.ncbi.nlm.nih.gov/7668294/
- tissue_or_cell_type
- Genomic DNA and whole-body probe metabolism
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 631–642
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CYP2A gene sequencing and coumarin metabolic phenotyping · source_derived_draft · unverified_draft
### coumarin-genetic-variation CYP2A6 variant alleles were identified in individuals with poor coumarin metabolism, including a single-amino-acid inactivating variant. Condition category: machinery_impairment nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Inherited enzyme differences can change how coumarin is processed. organism: Human tissue_or_cell_type: Genomic DNA and whole-body probe metabolism experimental_model: CYP2A gene sequencing and coumarin metabolic phenotyping limitations: Historical variant labels retained; no automatic mapping to modern star alleles and no demonstrated prediction of liver injury. exposure: Original CYP2A6v1/v2 nomenclature; poor-metabolizer individuals evidence_span: {"source_cache": "artifacts/coumarin-research/7668294.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "aeb377e6bbda1a552066c5d1caf1bf558753096627b863835637a0f2f942b3b1", "start_char": 0, "end_char": 1316, "text_sha256": "aeb377e6bbda1a552066c5d1caf1bf558753096627b863835637a0f2f942b3b1"} [coumarin-p7668294] A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (1995). https://pubmed.ncbi.nlm.nih.gov/7668294/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.