Component

Curcuma longa extract used in the 2020 knee trial

Curcuma longa extract used in the 2020 knee trial. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

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How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Lateral femoral cartilage T2 relaxation time did not change significantly.

    Curcuma longa extract used in the 2020 knee trial → Knee cartilage MRI T2 relaxation time source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/32926799.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e", "start_char": 0, "end_char": 1979, "text_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e"}
    experimental_model
    Randomized double-blind placebo-controlled trial in 70 adults
    exposure
    Two capsules/day of the specified Curcuma longa extract for 12 weeks
    limitations
    Mixed botanical extract; its effects cannot be assigned exclusively to curcumin. Small, short trial with pain and MRI outcomes.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    The trial did not establish cartilage repair.
    primary_references
    [curcumin-p32926799] Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32926799/ DOI: 10.7326/m20-0990
    tissue_or_cell_type
    Symptomatic knee osteoarthritis with effusion-synovitis

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1113–1124

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial in 70 adults · source_derived_draft · unverified_draft

    ### curcumin-knee-cartilage-null Lateral femoral cartilage T2 relaxation time did not change significantly. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The trial did not establish cartilage repair. organism: Homo sapiens tissue_or_cell_type: Symptomatic knee osteoarthritis with effusion-synovitis experimental_model: Randomized double-blind placebo-controlled trial in 70 adults limitations: Mixed botanical extract; its effects cannot be assigned exclusively to curcumin. Small, short trial with pain and MRI outcomes. exposure: Two capsules/day of the specified Curcuma longa extract for 12 weeks evidence_span: {"source_cache": "artifacts/curcumin-research/32926799.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e", "start_char": 0, "end_char": 1979, "text_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e"} [curcumin-p32926799] Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32926799/ DOI: 10.7326/m20-0990
    Complete structured claim and evidence

  2. VAS pain improved by 9.1 mm more than placebo; 95% CI for the difference was -17.8 to -0.4 mm.

    Curcuma longa extract used in the 2020 knee trial → Knee osteoarthritis pain score source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/32926799.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e", "start_char": 0, "end_char": 1979, "text_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e"}
    experimental_model
    Randomized double-blind placebo-controlled trial in 70 adults
    exposure
    Two capsules/day of the specified Curcuma longa extract for 12 weeks
    limitations
    Mixed botanical extract; its effects cannot be assigned exclusively to curcumin. Small, short trial with pain and MRI outcomes.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    The extract produced a modest average pain improvement.
    primary_references
    [curcumin-p32926799] Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32926799/ DOI: 10.7326/m20-0990
    tissue_or_cell_type
    Symptomatic knee osteoarthritis with effusion-synovitis

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1087–1098

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial in 70 adults · source_derived_draft · unverified_draft

    ### curcumin-knee-pain VAS pain improved by 9.1 mm more than placebo; 95% CI for the difference was -17.8 to -0.4 mm. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The extract produced a modest average pain improvement. organism: Homo sapiens tissue_or_cell_type: Symptomatic knee osteoarthritis with effusion-synovitis experimental_model: Randomized double-blind placebo-controlled trial in 70 adults limitations: Mixed botanical extract; its effects cannot be assigned exclusively to curcumin. Small, short trial with pain and MRI outcomes. exposure: Two capsules/day of the specified Curcuma longa extract for 12 weeks evidence_span: {"source_cache": "artifacts/curcumin-research/32926799.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e", "start_char": 0, "end_char": 1979, "text_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e"} [curcumin-p32926799] Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32926799/ DOI: 10.7326/m20-0990
    Complete structured claim and evidence

  3. MRI effusion-synovitis volume did not improve significantly.

    Curcuma longa extract used in the 2020 knee trial → Knee MRI effusion-synovitis volume source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/32926799.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e", "start_char": 0, "end_char": 1979, "text_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e"}
    experimental_model
    Randomized double-blind placebo-controlled trial in 70 adults
    exposure
    Two capsules/day of the specified Curcuma longa extract for 12 weeks
    limitations
    Mixed botanical extract; its effects cannot be assigned exclusively to curcumin. Small, short trial with pain and MRI outcomes.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    Pain improvement did not establish a reduction in this MRI inflammation measure.
    primary_references
    [curcumin-p32926799] Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32926799/ DOI: 10.7326/m20-0990
    tissue_or_cell_type
    Symptomatic knee osteoarthritis with effusion-synovitis

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1100–1111

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial in 70 adults · source_derived_draft · unverified_draft

    ### curcumin-knee-synovitis-null MRI effusion-synovitis volume did not improve significantly. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Pain improvement did not establish a reduction in this MRI inflammation measure. organism: Homo sapiens tissue_or_cell_type: Symptomatic knee osteoarthritis with effusion-synovitis experimental_model: Randomized double-blind placebo-controlled trial in 70 adults limitations: Mixed botanical extract; its effects cannot be assigned exclusively to curcumin. Small, short trial with pain and MRI outcomes. exposure: Two capsules/day of the specified Curcuma longa extract for 12 weeks evidence_span: {"source_cache": "artifacts/curcumin-research/32926799.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e", "start_char": 0, "end_char": 1979, "text_sha256": "4ca3be7297a1ef7c42d663b2238d3e53f58b5d21975f865c7cae7942681e990e"} [curcumin-p32926799] Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32926799/ DOI: 10.7326/m20-0990
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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