Component
Cucurbitacins
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In 353 French poison-center cases involving non-edible squash, 204 were symptomatic, predominantly with gastrointestinal effects; the series included dehydration or hypotension and recorded no severe cases or deaths.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human retrospective poison-center series; compound mixture, individual cucurbitacin identity and dose unmeasured.
- limitations
- Case-series selection and unquantified mixtures prevent member-specific dose-response inference; absence of deaths in this series is not universal safety.
- nutrient_topic
- Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Cucurbitacins
- plain_language
- Human exposure evidence includes poisoning, not just experimental anticancer effects.
- primary_references
- Poisoning by non-edible squash: retrospective series of 353 patients from French Poison Control Centers. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29323540/ · DOI 10.1080/15563650.2018.1424891
Cucurbitacins: thiol chemistry, cytoskeleton, metabolic dependencies and signaling (2026-09-20) · lines 396–402
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human retrospective poison-center series; compound mixture, individual cucurbitacin identity and dose unmeasured. · source_derived_draft · unverified_draft
## cucurbitacin-human-bitter-squash Human exposure evidence includes poisoning, not just experimental anticancer effects. In 353 French poison-center cases involving non-edible squash, 204 were symptomatic, predominantly with gastrointestinal effects; the series included dehydration or hypotension and recorded no severe cases or deaths. Model: Human retrospective poison-center series; compound mixture, individual cucurbitacin identity and dose unmeasured. Limitations: Case-series selection and unquantified mixtures prevent member-specific dose-response inference; absence of deaths in this series is not universal safety. Evidence access: Primary abstract Poisoning by non-edible squash: retrospective series of 353 patients from French Poison Control Centers. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29323540/ · DOI 10.1080/15563650.2018.1424891
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.