{"id":"5704214e-01b1-5519-a362-1d1fb4b8c27b","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-human-bitter-squash","predicate":"is_associated_with","statement":"In 353 French poison-center cases involving non-edible squash, 204 were symptomatic, predominantly with gastrointestinal effects; the series included dehydration or hypotension and recorded no severe cases or deaths.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"40f96f7c-d700-598a-add5-2036950ea313","mechanism_event_label":"Human exposure evidence includes poisoning, not just experimental anticancer effects.","subject":{"id":"26e8922d-b626-5cf9-aac6-aa1c06ad2c52","slug":"human-bitter-squash-exposure","display_name":"Human bitter-squash mixture exposure","entity_type_key":"cellular_process"},"object":{"id":"1c9d212f-84b6-5b97-9e97-1417a77c70e3","slug":"human-bitter-squash-poisoning","display_name":"Human bitter-squash gastrointestinal poisoning","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"40f96f7c-d700-598a-add5-2036950ea313","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-human-bitter-squash-event","event_type":"observed_relationship","label":"Human exposure evidence includes poisoning, not just experimental anticancer effects.","description":"In 353 French poison-center cases involving non-edible squash, 204 were symptomatic, predominantly with gastrointestinal effects; 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compound mixture, individual cucurbitacin identity and dose unmeasured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Case-series selection and unquantified mixtures prevent member-specific dose-response inference; absence of deaths in this series is not universal safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cucurbitacin","display_name":"Cucurbitacins","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Human exposure evidence includes poisoning, not just experimental anticancer effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Poisoning by non-edible squash: retrospective series of 353 patients from French Poison Control Centers. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29323540/ · DOI 10.1080/15563650.2018.1424891","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"99aa110f-ea42-5c5d-a3c0-4a8efb8258ec","evidence_kind":"source_excerpt","locator":"Lines 396-402","start_line":396,"end_line":402,"excerpt":"## cucurbitacin-human-bitter-squash\nHuman exposure evidence includes poisoning, not just experimental anticancer effects.\nIn 353 French poison-center cases involving non-edible squash, 204 were symptomatic, predominantly with gastrointestinal effects; the series included dehydration or hypotension and recorded no severe cases or deaths.\nModel: Human retrospective poison-center series; compound mixture, individual cucurbitacin identity and dose unmeasured.\nLimitations: Case-series selection and unquantified mixtures prevent member-specific dose-response inference; absence of deaths in this series is not universal safety.\nEvidence access: Primary abstract\nPoisoning by non-edible squash: retrospective series of 353 patients from French Poison Control Centers. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29323540/ · DOI 10.1080/15563650.2018.1424891","model_system":"Human retrospective poison-center series; compound mixture, individual cucurbitacin identity and dose unmeasured.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"77324310-00ce-5d28-9fc7-595fddae86b9","stable_key":"import-2921131d-0ba0-51d3-8f59-8c4be3b9ac08","title":"Cucurbitacins: thiol chemistry, cytoskeleton, metabolic dependencies and signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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