Component
Homozygous CTH Thr67Ile genotype
Human homozygosity for the CTH c.200C>T allele studied in 2009
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Vitamin B6 administration lowered plasma cystathionine in the reported CTH Thr67Ile homozygote.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- p.Thr67Ile section; Supplemental Table 3
- experimental_model
- Human families; expressed human CTH variants
- exposure
- Vitamin B6 administration reported for patient 2927; observational case context
- limitations
- Single genotype-specific case; not a treatment recommendation or evidence of deficiency.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- B6 responsiveness occurred in this particular enzyme genotype.
- primary_references
- [b6-cth-2009] Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. (2009). https://pmc.ncbi.nlm.nih.gov/articles/PMC2752209/ DOI: 10.1016/j.ymgme.2009.04.001
- tissue_or_cell_type
- Human plasma
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 577–588
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human families; expressed human CTH variants · source_derived_draft · unverified_draft
### b6-met-cth-t67i-clinical Vitamin B6 administration lowered plasma cystathionine in the reported CTH Thr67Ile homozygote. Condition category: machinery_impairment nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: B6 responsiveness occurred in this particular enzyme genotype. organism: Homo sapiens tissue_or_cell_type: Human plasma experimental_model: Human families; expressed human CTH variants limitations: Single genotype-specific case; not a treatment recommendation or evidence of deficiency. exposure: Vitamin B6 administration reported for patient 2927; observational case context evidence_location: p.Thr67Ile section; Supplemental Table 3 [b6-cth-2009] Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. (2009). https://pmc.ncbi.nlm.nih.gov/articles/PMC2752209/ DOI: 10.1016/j.ymgme.2009.04.001
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.