{"id":"30c00604-ff6e-5633-8ab6-e6cb0ffe6565","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-met-cth-t67i-clinical","predicate":"decreases","statement":"Vitamin B6 administration lowered plasma cystathionine in the reported CTH Thr67Ile homozygote.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"bdf3b0e9-737d-5776-9400-5a9a96e0f3fd","mechanism_event_label":"B6 responsiveness occurred in this particular enzyme genotype.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"0fdde942-b234-52c2-84aa-4c3bb0b6ab0b","slug":"plasma-cystathionine-concentration","display_name":"Plasma cystathionine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bdf3b0e9-737d-5776-9400-5a9a96e0f3fd","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-met-cth-t67i-clinical-event","event_type":"observed_intervention","label":"B6 responsiveness occurred in this particular enzyme genotype.","description":"Vitamin B6 administration lowered plasma cystathionine in the reported CTH Thr67Ile homozygote.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"79566be6-654a-5977-b088-82ac420cdf69","slug":"cth-t67i-homozygous-genotype","display_name":"Homozygous CTH Thr67Ile genotype","entity_type_key":"gene"},"role":"patient genotype","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ffc7d833-38ce-5224-82e0-19c0b87b45bf","slug":"cystathionine","display_name":"Cystathionine","entity_type_key":"small_molecule"},"role":"measured metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0fdde942-b234-52c2-84aa-4c3bb0b6ab0b","slug":"plasma-cystathionine-concentration","display_name":"Plasma cystathionine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"p.Thr67Ile section; Supplemental Table 3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human families; expressed human CTH variants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Vitamin B6 administration reported for patient 2927; observational case context","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single genotype-specific case; not a treatment recommendation or evidence of deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"B6 responsiveness occurred in this particular enzyme genotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-cth-2009] Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. (2009). https://pmc.ncbi.nlm.nih.gov/articles/PMC2752209/ DOI: 10.1016/j.ymgme.2009.04.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human plasma","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"75ea17b6-c08a-5225-b4dd-ebb9ebec13f0","evidence_kind":"source_excerpt","locator":"Lines 577-588","start_line":577,"end_line":588,"excerpt":"### b6-met-cth-t67i-clinical\nVitamin B6 administration lowered plasma cystathionine in the reported CTH Thr67Ile homozygote.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: B6 responsiveness occurred in this particular enzyme genotype.\norganism: Homo sapiens\ntissue_or_cell_type: Human plasma\nexperimental_model: Human families; expressed human CTH variants\nlimitations: Single genotype-specific case; not a treatment recommendation or evidence of deficiency.\nexposure: Vitamin B6 administration reported for patient 2927; observational case context\nevidence_location: p.Thr67Ile section; Supplemental Table 3\n[b6-cth-2009] Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. 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