Component
CSF 5-methyltetrahydrofolate concentration
Measurement in cerebrospinal fluid; distinct from plasma concentration.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Two siblings with FOLR1 Q118X/C175X variants had severe CSF folate depletion despite unremarkable plasma and erythrocyte folate.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Children with FOLR1 variants and patient fibroblasts
- exposure
- Inherited compound-heterozygous genotype
- limitations
- Observations in two siblings; does not generalize to common folate variation.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- Normal blood folate did not exclude impaired brain delivery.
- primary_references
- [steinfeld2009] Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism (2009). https://pubmed.ncbi.nlm.nih.gov/19732866/ DOI: 10.1016/j.ajhg.2009.08.005
- tissue_or_cell_type
- CSF, plasma and erythrocytes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 231–241
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Children with FOLR1 variants and patient fibroblasts · source_derived_draft · unverified_draft
### folate-folr1-csf-peripheral-dissociation Two siblings with FOLR1 Q118X/C175X variants had severe CSF folate depletion despite unremarkable plasma and erythrocyte folate. Condition category: machinery_impairment nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Normal blood folate did not exclude impaired brain delivery. organism: Homo sapiens tissue_or_cell_type: CSF, plasma and erythrocytes experimental_model: Children with FOLR1 variants and patient fibroblasts limitations: Observations in two siblings; does not generalize to common folate variation. exposure: Inherited compound-heterozygous genotype [steinfeld2009] Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism (2009). https://pubmed.ncbi.nlm.nih.gov/19732866/ DOI: 10.1016/j.ajhg.2009.08.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.