Component
Systemic exposure to unchanged coumarin
Systemic exposure to unchanged coumarin. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Approximately 1% of orally administered coumarin reached systemic circulation unchanged in this pilot study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/7263928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385", "start_char": 0, "end_char": 1084, "text_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385"}
- experimental_model
- Pilot oral, sustained-release and intravenous pharmacokinetic comparison
- exposure
- Coumarin formulations; full dosing not specified in abstract
- limitations
- Pilot formulation comparison; low parent exposure does not imply poor intestinal absorption.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human
- plain_language
- Absorbed coumarin was largely transformed before circulating unchanged.
- primary_references
- [coumarin-p7263928] Pilot study on bioavailability of coumarin and 7-hydroxycoumarin upon peroral administration of coumarin in a sustained-release dosage form. (1981). https://pubmed.ncbi.nlm.nih.gov/7263928/ DOI: 10.1002/j.1552-4604.1981.tb01770.x
- tissue_or_cell_type
- Whole blood
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 644–655
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pilot oral, sustained-release and intravenous pharmacokinetic comparison · source_derived_draft · unverified_draft
### coumarin-first-pass Approximately 1% of orally administered coumarin reached systemic circulation unchanged in this pilot study. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Absorbed coumarin was largely transformed before circulating unchanged. organism: Human tissue_or_cell_type: Whole blood experimental_model: Pilot oral, sustained-release and intravenous pharmacokinetic comparison limitations: Pilot formulation comparison; low parent exposure does not imply poor intestinal absorption. exposure: Coumarin formulations; full dosing not specified in abstract evidence_span: {"source_cache": "artifacts/coumarin-research/7263928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385", "start_char": 0, "end_char": 1084, "text_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385"} [coumarin-p7263928] Pilot study on bioavailability of coumarin and 7-hydroxycoumarin upon peroral administration of coumarin in a sustained-release dosage form. (1981). https://pubmed.ncbi.nlm.nih.gov/7263928/ DOI: 10.1002/j.1552-4604.1981.tb01770.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.