Component
Cinnamon powder capsule delivering 12 mg coumarin in the 2011 crossover study
Cinnamon powder capsule delivering 12 mg coumarin in the 2011 crossover study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Cinnamon-powder capsules produced 56.0% mean urinary metabolite recovery.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/21462332.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51d6682c94db1c278e08b499a03d6580c7a23d466c8faf9de1bcc30baaa36526", "start_char": 0, "end_char": 1240, "text_sha256": "51d6682c94db1c278e08b499a03d6580c7a23d466c8faf9de1bcc30baaa36526"}
- experimental_model
- Four-way crossover food-matrix bioavailability experiment
- exposure
- 24 healthy volunteers; each formulation delivered 12 mg coumarin; urinary means n=23 over 8 hours
- limitations
- Urinary metabolite recovery is an absorption proxy, not absolute unchanged-coumarin bioavailability; single-dose study.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human
- plain_language
- The cinnamon matrix still allowed substantial absorption.
- primary_references
- [coumarin-p21462332] Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. (2011). https://pubmed.ncbi.nlm.nih.gov/21462332/ DOI: 10.1002/mnfr.201000394
- tissue_or_cell_type
- Urine and plasma
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 683–694
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Four-way crossover food-matrix bioavailability experiment · source_derived_draft · unverified_draft
### coumarin-cinnamon-capsule-recovery Cinnamon-powder capsules produced 56.0% mean urinary metabolite recovery. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cinnamon matrix still allowed substantial absorption. organism: Human tissue_or_cell_type: Urine and plasma experimental_model: Four-way crossover food-matrix bioavailability experiment limitations: Urinary metabolite recovery is an absorption proxy, not absolute unchanged-coumarin bioavailability; single-dose study. exposure: 24 healthy volunteers; each formulation delivered 12 mg coumarin; urinary means n=23 over 8 hours evidence_span: {"source_cache": "artifacts/coumarin-research/21462332.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51d6682c94db1c278e08b499a03d6580c7a23d466c8faf9de1bcc30baaa36526", "start_char": 0, "end_char": 1240, "text_sha256": "51d6682c94db1c278e08b499a03d6580c7a23d466c8faf9de1bcc30baaa36526"} [coumarin-p21462332] Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. (2011). https://pubmed.ncbi.nlm.nih.gov/21462332/ DOI: 10.1002/mnfr.201000394
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.