Component
Human COQ8A / ADCK3
Human COQ8A / ADCK3. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human COQ8A showed ATPase activity as part of the conserved COQ8 biochemical function.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/29198567.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67", "start_char": 0, "end_char": 1050, "text_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67"}
- experimental_model
- Biochemistry and chemical genetics
- exposure
- Cardiolipin-containing membranes and phenolic compounds
- limitations
- Human ATPase chemistry and yeast inhibition are distinct model components.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Human COQ8A and yeast Coq8
- plain_language
- A protein once described mainly as kinase-like also uses ATP to support CoQ synthesis.
- primary_references
- [coq10-p29198567] Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. (2018). https://pubmed.ncbi.nlm.nih.gov/29198567/ DOI: 10.1016/j.chembiol.2017.11.001
- tissue_or_cell_type
- Membrane-regulated ATPase
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 320–331
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemistry and chemical genetics · source_derived_draft · unverified_draft
### coq10-coq8a-atpase Human COQ8A showed ATPase activity as part of the conserved COQ8 biochemical function. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A protein once described mainly as kinase-like also uses ATP to support CoQ synthesis. organism: Human COQ8A and yeast Coq8 tissue_or_cell_type: Membrane-regulated ATPase experimental_model: Biochemistry and chemical genetics limitations: Human ATPase chemistry and yeast inhibition are distinct model components. exposure: Cardiolipin-containing membranes and phenolic compounds evidence_span: {"source_cache": "artifacts/coq10-research/29198567.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67", "start_char": 0, "end_char": 1050, "text_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67"} [coq10-p29198567] Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. (2018). https://pubmed.ncbi.nlm.nih.gov/29198567/ DOI: 10.1016/j.chembiol.2017.11.001
Complete structured claim and evidence
Where it participates (unsigned role)
Binding to cardiolipin-containing membranes stimulated COQ8 ATPase activity.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/29198567.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67", "start_char": 0, "end_char": 1050, "text_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67"}
- experimental_model
- Biochemistry and chemical genetics
- exposure
- Cardiolipin-containing membranes and phenolic compounds
- limitations
- Human ATPase chemistry and yeast inhibition are distinct model components.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Human COQ8A and yeast Coq8
- plain_language
- The surrounding membrane can change how this biosynthesis helper works.
- primary_references
- [coq10-p29198567] Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. (2018). https://pubmed.ncbi.nlm.nih.gov/29198567/ DOI: 10.1016/j.chembiol.2017.11.001
- tissue_or_cell_type
- Membrane-regulated ATPase
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 333–344
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemistry and chemical genetics · source_derived_draft · unverified_draft
### coq10-coq8-cardiolipin Binding to cardiolipin-containing membranes stimulated COQ8 ATPase activity. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The surrounding membrane can change how this biosynthesis helper works. organism: Human COQ8A and yeast Coq8 tissue_or_cell_type: Membrane-regulated ATPase experimental_model: Biochemistry and chemical genetics limitations: Human ATPase chemistry and yeast inhibition are distinct model components. exposure: Cardiolipin-containing membranes and phenolic compounds evidence_span: {"source_cache": "artifacts/coq10-research/29198567.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67", "start_char": 0, "end_char": 1050, "text_sha256": "4719b64857834d1a9b54316220f3d33aa529dce36938da0a063c74c5a5f30f67"} [coq10-p29198567] Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. (2018). https://pubmed.ncbi.nlm.nih.gov/29198567/ DOI: 10.1016/j.chembiol.2017.11.001
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.