Component

Fast-conducting compound action potential in peripheral nerve

Fast-conducting compound action potential in peripheral nerve. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Capsaicin reversibly and concentration-dependently reduced the peak amplitude of the compound action potential, the TRPV1 antagonist capsazepine did not affect this activity, and the powerful TRPV1 agonist resiniferatoxin had no effect on compound action potentials, indicating no involvement of TRPV1 channels; capsaicin analogs and other vanilloids inhibited them in the same concentration-dependent way.

    Dihydrocapsaicin → Fast-conducting compound action potential in peripheral nerve source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dihydrocapsaicin-research/23352977.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb", "start_char": 0, "end_char": 1707, "text_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb"}
    experimental_model
    Compound action potentials recorded from frog sciatic nerve fibres by the air-gap method
    exposure
    Capsaicin, dihydrocapsaicin, capsiate, eugenol, guaiacol, zingerone, vanillin, vanillylamine, vanillic acid, olvanil and curcumin, against procaine
    limitations
    An isolated nerve preparation with a clean negative control for the receptor: capsazepine did not block the effect and resiniferatoxin, a more powerful TRPV1 agonist, had none. That makes this a non-TRPV1 action of both compounds.
    nutrient_topic
    Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
    organism
    Frog
    plain_language
    This block is not the famous receptor at work: blocking the receptor does not stop it, and a stronger agonist does not cause it.
    primary_references
    [dhc-p23352977] Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. (2013). https://pubmed.ncbi.nlm.nih.gov/23352977/ DOI: 10.1016/j.lfs.2013.01.011
    tissue_or_cell_type
    Sciatic nerve

    Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 127–138

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Compound action potentials recorded from frog sciatic nerve fibres by the air-gap method · source_derived_draft · unverified_draft

    ### dhc-conduction-block-not-trpv1 Capsaicin reversibly and concentration-dependently reduced the peak amplitude of the compound action potential, the TRPV1 antagonist capsazepine did not affect this activity, and the powerful TRPV1 agonist resiniferatoxin had no effect on compound action potentials, indicating no involvement of TRPV1 channels; capsaicin analogs and other vanilloids inhibited them in the same concentration-dependent way. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: This block is not the famous receptor at work: blocking the receptor does not stop it, and a stronger agonist does not cause it. organism: Frog tissue_or_cell_type: Sciatic nerve experimental_model: Compound action potentials recorded from frog sciatic nerve fibres by the air-gap method limitations: An isolated nerve preparation with a clean negative control for the receptor: capsazepine did not block the effect and resiniferatoxin, a more powerful TRPV1 agonist, had none. That makes this a non-TRPV1 action of both compounds. exposure: Capsaicin, dihydrocapsaicin, capsiate, eugenol, guaiacol, zingerone, vanillin, vanillylamine, vanillic acid, olvanil and curcumin, against procaine evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/23352977.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb", "start_char": 0, "end_char": 1707, "text_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb"} [dhc-p23352977] Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. (2013). https://pubmed.ncbi.nlm.nih.gov/23352977/ DOI: 10.1016/j.lfs.2013.01.011
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. In the efficacy sequence for inhibition of compound action potentials the order was capsaicin equal to dihydrocapsaicin, then capsiate, eugenol, guaiacol, zingerone, vanillin and vanillylamine, with capsaicin ten-fold more effective than procaine; the extent of inhibition is determined by the property of the side chain bound to the vanillyl group.

    Dihydrocapsaicin → Capsaicin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dihydrocapsaicin-research/23352977.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb", "start_char": 0, "end_char": 1707, "text_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb"}
    experimental_model
    Compound action potentials recorded from frog sciatic nerve fibres by the air-gap method
    exposure
    Capsaicin, dihydrocapsaicin, capsiate, eugenol, guaiacol, zingerone, vanillin, vanillylamine, vanillic acid, olvanil and curcumin, against procaine
    limitations
    An isolated nerve preparation with a clean negative control for the receptor: capsazepine did not block the effect and resiniferatoxin, a more powerful TRPV1 agonist, had none. That makes this a non-TRPV1 action of both compounds.
    nutrient_topic
    Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
    organism
    Frog
    plain_language
    For blocking nerve conduction the two compounds are equally strong, and stronger than a local anaesthetic.
    primary_references
    [dhc-p23352977] Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. (2013). https://pubmed.ncbi.nlm.nih.gov/23352977/ DOI: 10.1016/j.lfs.2013.01.011
    tissue_or_cell_type
    Sciatic nerve

    Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 114–125

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Compound action potentials recorded from frog sciatic nerve fibres by the air-gap method · source_derived_draft · unverified_draft

    ### dhc-equal-conduction-block In the efficacy sequence for inhibition of compound action potentials the order was capsaicin equal to dihydrocapsaicin, then capsiate, eugenol, guaiacol, zingerone, vanillin and vanillylamine, with capsaicin ten-fold more effective than procaine; the extent of inhibition is determined by the property of the side chain bound to the vanillyl group. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: For blocking nerve conduction the two compounds are equally strong, and stronger than a local anaesthetic. organism: Frog tissue_or_cell_type: Sciatic nerve experimental_model: Compound action potentials recorded from frog sciatic nerve fibres by the air-gap method limitations: An isolated nerve preparation with a clean negative control for the receptor: capsazepine did not block the effect and resiniferatoxin, a more powerful TRPV1 agonist, had none. That makes this a non-TRPV1 action of both compounds. exposure: Capsaicin, dihydrocapsaicin, capsiate, eugenol, guaiacol, zingerone, vanillin, vanillylamine, vanillic acid, olvanil and curcumin, against procaine evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/23352977.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb", "start_char": 0, "end_char": 1707, "text_sha256": "8a2b1f1a1bde0cfc3d08340f1951d88fb3711df6a40634a8c4c7bac63f8384bb"} [dhc-p23352977] Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. (2013). https://pubmed.ncbi.nlm.nih.gov/23352977/ DOI: 10.1016/j.lfs.2013.01.011
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards