Component

Cold-induced vasodilatation in the extremities

Cold-induced vasodilatation in the extremities. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

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Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Index-finger cooling produced cold-induced vasodilatation earlier than hand or forearm immersion (5.90 versus 7.95 and 9.26 minutes) and without significant cardiovascular change, whereas hand or forearm immersion produced a delayed and slower vasodilatation with bradycardia at the end of the test and a larger blood pressure rise.

    Cold water immersion → Cold-induced vasodilatation in the extremities source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/9202941.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c66741aac658e383d3e372a1c257db8dbcbce5e57d4dc053583181192f0c2e1", "start_char": 0, "end_char": 1846, "text_sha256": "0c66741aac658e383d3e372a1c257db8dbcbce5e57d4dc053583181192f0c2e1"}
    experimental_model
    Twenty subjects immersing finger, hand, or forearm and hand in 5 degrees C water
    exposure
    30 minutes of immersion at 5 degrees C followed by 15 minutes of recovery
    limitations
    The comparison of immersed areas is the point: the cardiovascular response depends on how much skin is cooled, not on the temperature alone.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    How much of you goes in the water decides what your heart and vessels do.
    primary_references
    [cold-p9202941] Cold induced vasodilatation and cardiovascular responses in humans during cold water immersion of various upper limb areas. (1997). https://pubmed.ncbi.nlm.nih.gov/9202941/ DOI: 10.1007/s004210050191
    tissue_or_cell_type
    Upper limb skin and cardiovascular system

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 221–232

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty subjects immersing finger, hand, or forearm and hand in 5 degrees C water · source_derived_draft · unverified_draft

    ### cold-civd-area-dependence Index-finger cooling produced cold-induced vasodilatation earlier than hand or forearm immersion (5.90 versus 7.95 and 9.26 minutes) and without significant cardiovascular change, whereas hand or forearm immersion produced a delayed and slower vasodilatation with bradycardia at the end of the test and a larger blood pressure rise. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: How much of you goes in the water decides what your heart and vessels do. organism: Human tissue_or_cell_type: Upper limb skin and cardiovascular system experimental_model: Twenty subjects immersing finger, hand, or forearm and hand in 5 degrees C water limitations: The comparison of immersed areas is the point: the cardiovascular response depends on how much skin is cooled, not on the temperature alone. exposure: 30 minutes of immersion at 5 degrees C followed by 15 minutes of recovery evidence_span: {"source_cache": "artifacts/cold-research/9202941.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c66741aac658e383d3e372a1c257db8dbcbce5e57d4dc053583181192f0c2e1", "start_char": 0, "end_char": 1846, "text_sha256": "0c66741aac658e383d3e372a1c257db8dbcbce5e57d4dc053583181192f0c2e1"} [cold-p9202941] Cold induced vasodilatation and cardiovascular responses in humans during cold water immersion of various upper limb areas. (1997). https://pubmed.ncbi.nlm.nih.gov/9202941/ DOI: 10.1007/s004210050191
    Complete structured claim and evidence

  2. The initial cold-induced vasoconstriction involved constriction of the arteriovenous anastomoses and the two main finger arteries, and during cold-induced vasodilatation the large blood flow and high skin temperature were caused by relaxation of the smooth muscle cells of the arteriovenous anastomoses, with velocity fluctuations synchronous with the uncooled control finger.

    Arteriovenous anastomoses of the finger → Cold-induced vasodilatation in the extremities source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/10070133.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "645f4eccd5fc06bd968b4fddd514e55561f4403ec1c2e3437beae785c006e19f", "start_char": 0, "end_char": 1121, "text_sha256": "645f4eccd5fc06bd968b4fddd514e55561f4403ec1c2e3437beae785c006e19f"}
    experimental_model
    Ultrasound Doppler of finger arteries during severe local cooling in 21 thermoneutral subjects
    exposure
    Local cooling at 3 degrees C for 30 to 45 minutes
    limitations
    Direct vessel-level measurement. It identifies which vessels open, and the synchrony with the control finger indicates central rather than purely local control.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    Specific shunt vessels clamp shut and then open again, and both hands do it together.
    primary_references
    [cold-p10070133] Perfusion of the human finger during cold-induced vasodilatation. (1999). https://pubmed.ncbi.nlm.nih.gov/10070133/ DOI: 10.1152/ajpregu.1999.276.3.r731
    tissue_or_cell_type
    Finger arteries and arteriovenous anastomoses

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 234–245

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ultrasound Doppler of finger arteries during severe local cooling in 21 thermoneutral subjects · source_derived_draft · unverified_draft

    ### cold-civd-ava-mechanism The initial cold-induced vasoconstriction involved constriction of the arteriovenous anastomoses and the two main finger arteries, and during cold-induced vasodilatation the large blood flow and high skin temperature were caused by relaxation of the smooth muscle cells of the arteriovenous anastomoses, with velocity fluctuations synchronous with the uncooled control finger. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Specific shunt vessels clamp shut and then open again, and both hands do it together. organism: Human tissue_or_cell_type: Finger arteries and arteriovenous anastomoses experimental_model: Ultrasound Doppler of finger arteries during severe local cooling in 21 thermoneutral subjects limitations: Direct vessel-level measurement. It identifies which vessels open, and the synchrony with the control finger indicates central rather than purely local control. exposure: Local cooling at 3 degrees C for 30 to 45 minutes evidence_span: {"source_cache": "artifacts/cold-research/10070133.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "645f4eccd5fc06bd968b4fddd514e55561f4403ec1c2e3437beae785c006e19f", "start_char": 0, "end_char": 1121, "text_sha256": "645f4eccd5fc06bd968b4fddd514e55561f4403ec1c2e3437beae785c006e19f"} [cold-p10070133] Perfusion of the human finger during cold-induced vasodilatation. (1999). https://pubmed.ncbi.nlm.nih.gov/10070133/ DOI: 10.1152/ajpregu.1999.276.3.r731
    Complete structured claim and evidence

In the sources

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