Component
Mammalian ClC-4 chloride/proton exchanger
Mammalian ClC-4 chloride/proton exchanger. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
ClC-4 also supported secondary active proton transport in the expression assay.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/16034421.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a437e5233f3bb917ef5bbfee37e6eaed1745baf86fd4f35c85d8ad509dfa0f0", "start_char": 0, "end_char": 1359, "text_sha256": "3a437e5233f3bb917ef5bbfee37e6eaed1745baf86fd4f35c85d8ad509dfa0f0"}
- experimental_model
- Voltage and proton-flux measurements
- exposure
- Positive voltage and pore-glutamate mutation
- limitations
- Heterologous measurements; intracellular physiological direction depends on gradients.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Mammalian ClC constructs in expression systems
- plain_language
- The related ClC-4 protein is separately represented as an exchanger.
- primary_references
- [chloride-p16034421] Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. (2005). https://pubmed.ncbi.nlm.nih.gov/16034421/ DOI: 10.1038/nature03720
- tissue_or_cell_type
- Plasma-membrane-expressed transport proteins
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 653–664
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Voltage and proton-flux measurements · source_derived_draft · unverified_draft
### chloride-clc4-exchange ClC-4 also supported secondary active proton transport in the expression assay. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: The related ClC-4 protein is separately represented as an exchanger. organism: Mammalian ClC constructs in expression systems tissue_or_cell_type: Plasma-membrane-expressed transport proteins experimental_model: Voltage and proton-flux measurements limitations: Heterologous measurements; intracellular physiological direction depends on gradients. exposure: Positive voltage and pore-glutamate mutation evidence_span: {"source_cache": "artifacts/chloride-research/16034421.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3a437e5233f3bb917ef5bbfee37e6eaed1745baf86fd4f35c85d8ad509dfa0f0", "start_char": 0, "end_char": 1359, "text_sha256": "3a437e5233f3bb917ef5bbfee37e6eaed1745baf86fd4f35c85d8ad509dfa0f0"} [chloride-p16034421] Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. (2005). https://pubmed.ncbi.nlm.nih.gov/16034421/ DOI: 10.1038/nature03720
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.