Component
Urinary loss of administered citrulline
Urinary loss of administered citrulline. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Less than 5% of administered citrulline was excreted in urine, even at the higher tested doses.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/citrulline-research/17953788.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b57ecb5b3484e857904f38ae7c5d5eea51177e2e0a9a9c15ba5f81c2200a11bd", "start_char": 0, "end_char": 1603, "text_sha256": "b57ecb5b3484e857904f38ae7c5d5eea51177e2e0a9a9c15ba5f81c2200a11bd"}
- experimental_model
- Randomized-order oral dose-loading study
- exposure
- Separate 2, 5, 10 and 15 g citrulline loads
- limitations
- Small acute tolerance study; saturation was an interpretation, not directly localized or measured renal enzyme saturation.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human, eight healthy fasting men
- plain_language
- Most of the dose was not simply lost unchanged in urine.
- primary_references
- [citrulline-p17953788] Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. (2008). https://pubmed.ncbi.nlm.nih.gov/17953788/ DOI: 10.1017/s0007114507841110
- tissue_or_cell_type
- Plasma amino acids and 24-hour urine
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 944–955
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order oral dose-loading study · source_derived_draft · unverified_draft
### citrulline-urine-retention Less than 5% of administered citrulline was excreted in urine, even at the higher tested doses. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Most of the dose was not simply lost unchanged in urine. organism: Human, eight healthy fasting men tissue_or_cell_type: Plasma amino acids and 24-hour urine experimental_model: Randomized-order oral dose-loading study limitations: Small acute tolerance study; saturation was an interpretation, not directly localized or measured renal enzyme saturation. exposure: Separate 2, 5, 10 and 15 g citrulline loads evidence_span: {"source_cache": "artifacts/citrulline-research/17953788.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b57ecb5b3484e857904f38ae7c5d5eea51177e2e0a9a9c15ba5f81c2200a11bd", "start_char": 0, "end_char": 1603, "text_sha256": "b57ecb5b3484e857904f38ae7c5d5eea51177e2e0a9a9c15ba5f81c2200a11bd"} [citrulline-p17953788] Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. (2008). https://pubmed.ncbi.nlm.nih.gov/17953788/ DOI: 10.1017/s0007114507841110
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.