Component
Entry of skin-generated cholecalciferol into circulation
Transfer of newly formed D3 from cutaneous compartments into blood.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Vitamin D-binding protein preferentially translocated thermally formed cholecalciferol from the skin into circulation in the reported photochemistry experiments.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary abstract; skin photochemistry and transport experiments.
- experimental_model
- Human skin-to-circulation vitamin transport
- exposure
- After UV generation and thermal conversion; quantitative carrier concentrations unavailable in abstract.
- limitations
- Preferential transport is not proof that every route of D3 entry requires DBP.
- nutrient
- Vitamin D2 and D3 · Vitamin D2 and D3
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- A carrier helps newly made D3 enter the blood.
- primary_references
- [holick1980] Photosynthesis of previtamin D3 in human skin and the physiologic consequences. (1980). https://pubmed.ncbi.nlm.nih.gov/6251551/ DOI: 10.1126/science.6251551
- tissue_or_cell_type
- skin and circulation
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 121–134
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human skin-to-circulation vitamin transport · source_derived_draft · unverified_draft
### vd-act-dbp-skin-export Vitamin D-binding protein preferentially translocated thermally formed cholecalciferol from the skin into circulation in the reported photochemistry experiments. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A carrier helps newly made D3 enter the blood. organism: Homo sapiens tissue_or_cell_type: skin and circulation experimental_model: Human skin-to-circulation vitamin transport limitations: Preferential transport is not proof that every route of D3 entry requires DBP. exposure: After UV generation and thermal conversion; quantitative carrier concentrations unavailable in abstract. cross_nutrient: false evidence_location: Primary abstract; skin photochemistry and transport experiments. nutrient: Vitamin D2 and D3 [holick1980] Photosynthesis of previtamin D3 in human skin and the physiologic consequences. (1980). https://pubmed.ncbi.nlm.nih.gov/6251551/ DOI: 10.1126/science.6251551
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.