Component

Circulating arginine concentration

Circulating arginine concentration. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Oral citrulline increased plasma arginine AUC and peak concentration dose-dependently, more effectively than the tested oral arginine regimens.

    L-Citrulline → Circulating arginine concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/citrulline-research/17662090.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b", "start_char": 0, "end_char": 1980, "text_sha256": "32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b"}
    experimental_model
    Double-blind placebo-controlled crossover study
    exposure
    Citrulline 0.75, 1.5 or 3 g twice daily versus arginine formulations; one-week periods
    limitations
    Small short trial; NO-related urine markers do not establish a clinically meaningful vascular benefit.
    nutrient_topic
    Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
    organism
    Human, 20 healthy volunteers
    plain_language
    Taking the precursor can raise circulating arginine efficiently.
    primary_references
    [citrulline-p17662090] Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. (2008). https://pubmed.ncbi.nlm.nih.gov/17662090/ DOI: 10.1111/j.1365-2125.2007.02990.x
    tissue_or_cell_type
    Plasma amino acids, urine NO markers and brachial FMD

    Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 866–877

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled crossover study · source_derived_draft · unverified_draft

    ### citrulline-oral-arginine Oral citrulline increased plasma arginine AUC and peak concentration dose-dependently, more effectively than the tested oral arginine regimens. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Taking the precursor can raise circulating arginine efficiently. organism: Human, 20 healthy volunteers tissue_or_cell_type: Plasma amino acids, urine NO markers and brachial FMD experimental_model: Double-blind placebo-controlled crossover study limitations: Small short trial; NO-related urine markers do not establish a clinically meaningful vascular benefit. exposure: Citrulline 0.75, 1.5 or 3 g twice daily versus arginine formulations; one-week periods evidence_span: {"source_cache": "artifacts/citrulline-research/17662090.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b", "start_char": 0, "end_char": 1980, "text_sha256": "32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b"} [citrulline-p17662090] Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. (2008). https://pubmed.ncbi.nlm.nih.gov/17662090/ DOI: 10.1111/j.1365-2125.2007.02990.x
    Complete structured claim and evidence

  2. Citrulline supplementation increased plasma citrulline seventeenfold and arginine threefold in the SBS trial.

    L-Citrulline → Circulating arginine concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/citrulline-research/30642738.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737", "start_char": 0, "end_char": 2343, "text_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737"}
    experimental_model
    Double-blind crossover isotope study
    exposure
    0.18 g/kg/day citrulline for seven days versus isonitrogenous placebo
    limitations
    Near-normal nutritional status long after surgery; exploratory low-baseline subgroups were too small for a treatment rule.
    nutrient_topic
    Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
    organism
    Human, nine adults with stable nonmalignant short-bowel syndrome
    plain_language
    The oral precursor reached blood and increased downstream arginine.
    primary_references
    [citrulline-p30642738] Effect of oral citrulline supplementation on whole body protein metabolism in adult patients with short bowel syndrome: A pilot, randomized, double-blind, cross-over study. (2019). https://pubmed.ncbi.nlm.nih.gov/30642738/ DOI: 10.1016/j.clnu.2018.12.030
    tissue_or_cell_type
    Whole-body protein metabolism

    Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 1087–1098

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind crossover isotope study · source_derived_draft · unverified_draft

    ### citrulline-sbs-exposure Citrulline supplementation increased plasma citrulline seventeenfold and arginine threefold in the SBS trial. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The oral precursor reached blood and increased downstream arginine. organism: Human, nine adults with stable nonmalignant short-bowel syndrome tissue_or_cell_type: Whole-body protein metabolism experimental_model: Double-blind crossover isotope study limitations: Near-normal nutritional status long after surgery; exploratory low-baseline subgroups were too small for a treatment rule. exposure: 0.18 g/kg/day citrulline for seven days versus isonitrogenous placebo evidence_span: {"source_cache": "artifacts/citrulline-research/30642738.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737", "start_char": 0, "end_char": 2343, "text_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737"} [citrulline-p30642738] Effect of oral citrulline supplementation on whole body protein metabolism in adult patients with short bowel syndrome: A pilot, randomized, double-blind, cross-over study. (2019). https://pubmed.ncbi.nlm.nih.gov/30642738/ DOI: 10.1016/j.clnu.2018.12.030
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Plasma arginine rose, but NO-related measurements were reduced or unimproved versus placebo.

    L-Arginine → NO availability markers in peripheral arterial disease source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    NO-PAIN: 133 PAD patients, 3 g/day for six months.
    limitations
    Endpoint-dependent pattern; not every marker necessarily decreased.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    Higher blood availability did not ensure better pathway output.
    primary_references
    L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17592080/ · DOI 10.1161/circulationaha.106.683656

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 390–396

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · NO-PAIN: 133 PAD patients, 3 g/day for six months. · source_derived_draft · unverified_draft

    ## arg-pad-markers Higher blood availability did not ensure better pathway output. Plasma arginine rose, but NO-related measurements were reduced or unimproved versus placebo. Model: NO-PAIN: 133 PAD patients, 3 g/day for six months. Limitations: Endpoint-dependent pattern; not every marker necessarily decreased. Evidence access: Primary abstract L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17592080/ · DOI 10.1161/circulationaha.106.683656
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards