Component
Entrainment of a free-running circadian rhythm to 24 hours
Entrainment of a free-running circadian rhythm to 24 hours. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Six of seven participants entrained to a 24-hour rhythm during melatonin treatment, unlike placebo.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/11027741.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ef0d484e68b993c88b611d48f4cd8dc16db62056baa76f41f508818cccf78641", "start_char": 0, "end_char": 1749, "text_sha256": "ef0d484e68b993c88b611d48f4cd8dc16db62056baa76f41f508818cccf78641"}
- experimental_model
- Placebo crossover entrainment study
- exposure
- 10 mg daily before preferred bedtime; three participants later tapered to 0.5 mg after entrainment
- limitations
- Small selected population. Not all blindness causes free-running rhythms; these findings do not establish general insomnia efficacy.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Seven totally blind people with free-running rhythms
- plain_language
- An external timing signal can synchronize a free-running clock.
- primary_references
- [melatonin-p11027741] Entrainment of free-running circadian rhythms by melatonin in blind people. (2000). https://pubmed.ncbi.nlm.nih.gov/11027741/ DOI: 10.1056/nejm200010123431503
- tissue_or_cell_type
- Circadian phase and polysomnography
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 916–927
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo crossover entrainment study · source_derived_draft · unverified_draft
### melatonin-blind-entrainment Six of seven participants entrained to a 24-hour rhythm during melatonin treatment, unlike placebo. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: An external timing signal can synchronize a free-running clock. organism: Seven totally blind people with free-running rhythms tissue_or_cell_type: Circadian phase and polysomnography experimental_model: Placebo crossover entrainment study limitations: Small selected population. Not all blindness causes free-running rhythms; these findings do not establish general insomnia efficacy. exposure: 10 mg daily before preferred bedtime; three participants later tapered to 0.5 mg after entrainment evidence_span: {"source_cache": "artifacts/melatonin-research/11027741.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ef0d484e68b993c88b611d48f4cd8dc16db62056baa76f41f508818cccf78641", "start_char": 0, "end_char": 1749, "text_sha256": "ef0d484e68b993c88b611d48f4cd8dc16db62056baa76f41f508818cccf78641"} [melatonin-p11027741] Entrainment of free-running circadian rhythms by melatonin in blind people. (2000). https://pubmed.ncbi.nlm.nih.gov/11027741/ DOI: 10.1056/nejm200010123431503
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.