Component
Clickable cinnamaldehyde derivatives in the 2007 TRPA1 study
Clickable cinnamaldehyde derivatives in the 2007 TRPA1 study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Clickable cinnamaldehyde derivatives covalently labeled mouse TRPA1 in the channel-activation study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ceylon-research/17237762.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3f3cf7448cf3b27c466e1587bbd8a12dea9edb0910d27deab5129c356511943f", "start_char": 0, "end_char": 1420, "text_sha256": "3f3cf7448cf3b27c466e1587bbd8a12dea9edb0910d27deab5129c356511943f"}
- experimental_model
- Click-chemistry protein labeling and electrophysiology
- exposure
- Clickable cinnamaldehyde derivatives; reactive-cysteine probes
- limitations
- Derivative labeling is kept separate from unmodified cinnamaldehyde; cysteine mapping by iodoacetamide does not identify a cinnamaldehyde adduct at every mapped site.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Mouse TRPA1 expression systems
- plain_language
- A modified cinnamaldehyde probe attached to the channel protein, supporting a reactive-chemical sensing mechanism.
- primary_references
- [ceylon-p17237762] Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. (2007). https://pubmed.ncbi.nlm.nih.gov/17237762/ DOI: 10.1038/nature05544
- tissue_or_cell_type
- Ion-channel preparations
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 324–335
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Click-chemistry protein labeling and electrophysiology · source_derived_draft · unverified_draft
### ceylon-mouse-channel-adduct Clickable cinnamaldehyde derivatives covalently labeled mouse TRPA1 in the channel-activation study. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: A modified cinnamaldehyde probe attached to the channel protein, supporting a reactive-chemical sensing mechanism. organism: Mouse TRPA1 expression systems tissue_or_cell_type: Ion-channel preparations experimental_model: Click-chemistry protein labeling and electrophysiology limitations: Derivative labeling is kept separate from unmodified cinnamaldehyde; cysteine mapping by iodoacetamide does not identify a cinnamaldehyde adduct at every mapped site. exposure: Clickable cinnamaldehyde derivatives; reactive-cysteine probes evidence_span: {"source_cache": "artifacts/ceylon-research/17237762.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3f3cf7448cf3b27c466e1587bbd8a12dea9edb0910d27deab5129c356511943f", "start_char": 0, "end_char": 1420, "text_sha256": "3f3cf7448cf3b27c466e1587bbd8a12dea9edb0910d27deab5129c356511943f"} [ceylon-p17237762] Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. (2007). https://pubmed.ncbi.nlm.nih.gov/17237762/ DOI: 10.1038/nature05544
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.