Component

Human calcium and integrin-binding protein 1 / CIB1

Human calcium and integrin-binding protein 1 / CIB1

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. CIB1 knockdown or knockout reduced cADPR production in the type-III CD38 study.

    Human calcium and integrin-binding protein 1 / CIB1 → Cyclic ADP-ribose Recorded from sourceungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    experimental_contrast
    {"intervention": "CIB1 knockdown or knockout", "comparator": "Matched CIB1-intact controls", "endpoint": "CIB1 knockdown or knockout reduced cADPR production in the type-III CD38 study.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Human-cell perturbation experiments; primary abstract.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    CIB1 knockdown or knockout reduced cADPR production in the type-III CD38 study.
    primary_references
    Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. | https://pubmed.ncbi.nlm.nih.gov/28720704/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC5547619/ | https://doi.org/10.1073/pnas.1703718114
    source_locator
    Reviewed reference api-cib1-loss; No apigenin intervention. This is a requirement test for intracellular CD38 regulation, not evidence of impaired dietary calcium supply.
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 288–294

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Human-cell perturbation experiments; primary abstract. · Recorded from source · Recorded from source

    ### api-cib1-loss CIB1 knockdown or knockout reduced cADPR production in the type-III CD38 study. No apigenin intervention. This is a requirement test for intracellular CD38 regulation, not evidence of impaired dietary calcium supply. Model and exposure: Human-cell perturbation experiments; primary abstract. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28720704/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC5547619/ | https://doi.org/10.1073/pnas.1703718114 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    Complete structured claim and evidence

  2. CIB1 interacted with cytosol-facing type-III CD38 in the reported human-cell models.

    Human calcium and integrin-binding protein 1 / CIB1 → Human CD38 Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    experimental_model
    Human myeloma cells and topology-sensitive nanobody assays.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    CIB1 interacted with cytosol-facing type-III CD38 in the reported human-cell models.
    primary_references
    Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. | https://pubmed.ncbi.nlm.nih.gov/28720704/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC5547619/ | https://doi.org/10.1073/pnas.1703718114
    source_locator
    Reviewed reference api-cib1-typeiii; This study did not test apigenin. Cytosolic and extracellular CD38 topology are not interchangeable.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 280–286

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Human myeloma cells and topology-sensitive nanobody assays. · Recorded from source · Recorded from source

    ### api-cib1-typeiii CIB1 interacted with cytosol-facing type-III CD38 in the reported human-cell models. This study did not test apigenin. Cytosolic and extracellular CD38 topology are not interchangeable. Model and exposure: Human myeloma cells and topology-sensitive nanobody assays. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28720704/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC5547619/ | https://doi.org/10.1073/pnas.1703718114 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.