Component
Formation of chromium–small-molecule–DNA ternary adducts
Formation of chromium–small-molecule–DNA ternary adducts. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The characterized pre-reacted Cr(III)-cysteine, -glutathione and -ascorbate preparations did not measurably bind DNA or form the proposed ternary adducts under the tested conditions.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/36662348.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "500f334d72ca34561016a11f0c3bf866998ee364085855e54a2f29025bc916a8", "start_char": 0, "end_char": 1155, "text_sha256": "500f334d72ca34561016a11f0c3bf866998ee364085855e54a2f29025bc916a8"}
- experimental_model
- Characterization of pre-reacted chromium-ligand preparations and DNA-binding assays
- exposure
- Pre-reacted chromium cysteinate, chromium glutathione and chromium ascorbate preparations
- limitations
- These preparation-specific results challenge earlier assignments but do not show that Cr(VI) is harmless or directly reproduce every reductive chromate-DNA reaction.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Cell-free chemistry
- plain_language
- Pre-forming a metal complex can give a different result from reducing chromate in the presence of DNA; the claimed lesion identity needs checking.
- primary_references
- [chromium-p36662348] Examining the Potential Formation of Ternary DNA Complexes with Chromium‑Cysteine, Chromium-Ascorbate, and Chromium-Glutathione and Implications for Their Carcinogenicity. (2023). https://pubmed.ncbi.nlm.nih.gov/36662348/ DOI: 10.1007/s12011-023-03573-8
- tissue_or_cell_type
- Defined chromium complexes and DNA
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 1186–1197
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Characterization of pre-reacted chromium-ligand preparations and DNA-binding assays · source_derived_draft · unverified_draft
### chromium-prereacted-dna-binding-null The characterized pre-reacted Cr(III)-cysteine, -glutathione and -ascorbate preparations did not measurably bind DNA or form the proposed ternary adducts under the tested conditions. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Pre-forming a metal complex can give a different result from reducing chromate in the presence of DNA; the claimed lesion identity needs checking. organism: Cell-free chemistry tissue_or_cell_type: Defined chromium complexes and DNA experimental_model: Characterization of pre-reacted chromium-ligand preparations and DNA-binding assays limitations: These preparation-specific results challenge earlier assignments but do not show that Cr(VI) is harmless or directly reproduce every reductive chromate-DNA reaction. exposure: Pre-reacted chromium cysteinate, chromium glutathione and chromium ascorbate preparations evidence_span: {"source_cache": "artifacts/chromium-research/36662348.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "500f334d72ca34561016a11f0c3bf866998ee364085855e54a2f29025bc916a8", "start_char": 0, "end_char": 1155, "text_sha256": "500f334d72ca34561016a11f0c3bf866998ee364085855e54a2f29025bc916a8"} [chromium-p36662348] Examining the Potential Formation of Ternary DNA Complexes with Chromium‑Cysteine, Chromium-Ascorbate, and Chromium-Glutathione and Implications for Their Carcinogenicity. (2023). https://pubmed.ncbi.nlm.nih.gov/36662348/ DOI: 10.1007/s12011-023-03573-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.