Component
Cholesterol biosynthesis
Cellular production of cholesterol; tracer-specific measurement context is retained.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In HepG2 cells, gamma-tocotrienol inhibited incorporation of [14C]acetate into cholesterol with approximately 50% inhibition at 2 µM and maximal approximately 80% inhibition within 6 h, while incorporation of [3H]mevalonate was not inhibited.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Radiolabeled precursor incorporation in HepG2 cells
- exposure
- Gamma-tocotrienol approximately 2 µM for half-maximal inhibition; response developed within 6 h.
- limitations
- Primary abstract only; media and viability protocol unavailable. Tracer localization supports action upstream of mevalonate use, not a human cholesterol-lowering recommendation.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- Gamma-tocotrienol reduced cholesterol production from an early precursor, while leaving production from the later precursor mevalonate intact in cultured liver cells.
- primary_references
- [parker1993] Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1993). https://pubmed.ncbi.nlm.nih.gov/8388388/ DOI: 10.1016/s0021-9258(18)82115-9
- tissue_or_cell_type
- Hepatoma cell culture
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1102–1113
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiolabeled precursor incorporation in HepG2 cells · source_derived_draft · unverified_draft
### e-sig-gamma-te-cholesterol In HepG2 cells, gamma-tocotrienol inhibited incorporation of [14C]acetate into cholesterol with approximately 50% inhibition at 2 µM and maximal approximately 80% inhibition within 6 h, while incorporation of [3H]mevalonate was not inhibited. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Gamma-tocotrienol reduced cholesterol production from an early precursor, while leaving production from the later precursor mevalonate intact in cultured liver cells. organism: Homo sapiens tissue_or_cell_type: Hepatoma cell culture experimental_model: Radiolabeled precursor incorporation in HepG2 cells limitations: Primary abstract only; media and viability protocol unavailable. Tracer localization supports action upstream of mevalonate use, not a human cholesterol-lowering recommendation. exposure: Gamma-tocotrienol approximately 2 µM for half-maximal inhibition; response developed within 6 h. cross_nutrient: false [parker1993] Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1993). https://pubmed.ncbi.nlm.nih.gov/8388388/ DOI: 10.1016/s0021-9258(18)82115-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.