Intestinal cholesterol absorption

Where it participates (unsigned role)

1. Native oat bran increased median excretion of bile acids by 144%, cholesterol excretion remained unchanged while cholesterol absorption decreased by 19% and the sum of bile acid and cholesterol excretion increased by 40% compared with hydrolysed oat bran, 7-alpha-hydroxy-4-cholesten-3-one reflecting bile acid synthesis increased by 57% within 24 hours of consumption while serum lathosterol concentration reflecting cholesterol synthesis increased by 12%, and these effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

   Oat mixed-linkage beta-(1->3)/(1->4)-glucan → Faecal bile acid excretion source_derived_draftungraded
   Experimental context and source evidence

   availability_state

   biomarker_context Imported condition classification; unverified.

   evidence_span

   {"source_cache": "artifacts/glucan-research/17251929.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "96f0086004af03cea2b782fa14daef71ac29df5df3f790a2291fe375151c87b5", "start_char": 0, "end_char": 1618, "text_sha256": "96f0086004af03cea2b782fa14daef71ac29df5df3f790a2291fe375151c87b5"}

   experimental_model

   Crossover ileostomy study in nine volunteers with direct measurement of ileal output

   exposure

   Seventy-five grams of extruded oat bran cereal daily providing 11.6 grams of native or enzymatically hydrolysed beta-glucans over two 3-day periods

   limitations

   Nine ileostomy volunteers, which is what makes direct measurement of what leaves the small intestine possible. The comparator is the same material depolymerised, so the difference is attributable to the polymer rather than to the food.

   nutrient_topic

   Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. · Beta-glucan

   organism

   Human

   plain_language

   The intact polymer swept bile acids out of the small intestine within a day, and the liver started making replacements.

   primary_references

   [bg-p17251929] Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. (2007). https://pubmed.ncbi.nlm.nih.gov/17251929/ DOI: 10.1038/sj.ejcn.1602607

   tissue_or_cell_type

   Terminal ileum and serum

   trigger_kind

   biomarker_context Imported condition classification; unverified.

   Beta-glucan: a structural family rather than an agent, what decides whether a bound glucan actually signals, the complement route that a cereal and a yeast preparation share, and the unequal human evidence behind each (2026-09-22) · lines 541–552

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Crossover ileostomy study in nine volunteers with direct measurement of ileal output · source_derived_draft · unverified_draft

   ### bg-viscosity-drives-out-bile-acids Native oat bran increased median excretion of bile acids by 144%, cholesterol excretion remained unchanged while cholesterol absorption decreased by 19% and the sum of bile acid and cholesterol excretion increased by 40% compared with hydrolysed oat bran, 7-alpha-hydroxy-4-cholesten-3-one reflecting bile acid synthesis increased by 57% within 24 hours of consumption while serum lathosterol concentration reflecting cholesterol synthesis increased by 12%, and these effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity. Condition category: biomarker_context nutrient_topic: Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. plain_language: The intact polymer swept bile acids out of the small intestine within a day, and the liver started making replacements. organism: Human tissue_or_cell_type: Terminal ileum and serum experimental_model: Crossover ileostomy study in nine volunteers with direct measurement of ileal output limitations: Nine ileostomy volunteers, which is what makes direct measurement of what leaves the small intestine possible. The comparator is the same material depolymerised, so the difference is attributable to the polymer rather than to the food. exposure: Seventy-five grams of extruded oat bran cereal daily providing 11.6 grams of native or enzymatically hydrolysed beta-glucans over two 3-day periods evidence_span: {"source_cache": "artifacts/glucan-research/17251929.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "96f0086004af03cea2b782fa14daef71ac29df5df3f790a2291fe375151c87b5", "start_char": 0, "end_char": 1618, "text_sha256": "96f0086004af03cea2b782fa14daef71ac29df5df3f790a2291fe375151c87b5"} [bg-p17251929] Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. (2007). https://pubmed.ncbi.nlm.nih.gov/17251929/ DOI: 10.1038/sj.ejcn.1602607

   Complete structured claim and evidence