Component
Total loose or watery stools after enrollment
Total loose or watery stools after enrollment; read each linked claim for the measured context and model.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Diarrhea beyond five days occurred in 6.5%, 7.7% and 7.2% of the 20, 10 and 5 mg groups. The lower doses met the four-percentage-point noninferiority margin; stool counts also met the two-stool margin.
Experimental context and source evidence
- cross_nutrient
- Total loose or watery stools after enrollment (co_primary_endpoint)
- evidence_location
- Indexed primary abstract; accessible manuscript Methods and Results also inspected.
- evidence_span
- {"source_cache": "artifacts/zinc-clinical-sources/dhingra2020.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "48deafc698125c49384f5678bf65f3af2a4fc3359510f29a9a94a6b4991ee03e", "utf8_bytes": 2238}
- experimental_model
- Double-blind randomized multicenter noninferiority trial in 4500 children aged 6–59 months in India and Tanzania
- exposure
- 5, 10 or 20 mg zinc/day using zinc sulfate for 14 days.
- limitations
- Active-dose comparisons without a placebo arm. Noninferiority depends on the prespecified margin; not proof that doses are identical. Historical regimens are not current dosing guidance.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- The tested lower doses preserved trial-defined efficacy.
- primary_references
- [zn-clin-dhingra2020] Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32966722/ DOI: 10.1056/nejmoa1915905
- published_estimates
- 10 versus 20 mg: risk difference 1.2 percentage points, upper 98.75% CI 3.3; 5 versus 20 mg: 0.7, upper 2.8. Mean stools 10.7, 10.9, 10.8 (20,10,5 mg); reported differences 0.3 (upper 1.0) and 0.1 (upper 0.8). Indexed published version used; source-version differences retained in paper notes.
- tissue_or_cell_type
- Acute diarrheal illness and vomiting
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1512–1526
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized multicenter noninferiority trial in 4500 children aged 6–59 months in India and Tanzania · source_derived_draft · unverified_draft
### zn-clin-diarrhea-dose-efficacy Diarrhea beyond five days occurred in 6.5%, 7.7% and 7.2% of the 20, 10 and 5 mg groups. The lower doses met the four-percentage-point noninferiority margin; stool counts also met the two-stool margin. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested lower doses preserved trial-defined efficacy. organism: Homo sapiens tissue_or_cell_type: Acute diarrheal illness and vomiting experimental_model: Double-blind randomized multicenter noninferiority trial in 4500 children aged 6–59 months in India and Tanzania limitations: Active-dose comparisons without a placebo arm. Noninferiority depends on the prespecified margin; not proof that doses are identical. Historical regimens are not current dosing guidance. exposure: 5, 10 or 20 mg zinc/day using zinc sulfate for 14 days. cross_nutrient: Total loose or watery stools after enrollment (co_primary_endpoint) evidence_location: Indexed primary abstract; accessible manuscript Methods and Results also inspected. evidence_span: {"source_cache": "artifacts/zinc-clinical-sources/dhingra2020.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "48deafc698125c49384f5678bf65f3af2a4fc3359510f29a9a94a6b4991ee03e", "utf8_bytes": 2238} published_estimates: 10 versus 20 mg: risk difference 1.2 percentage points, upper 98.75% CI 3.3; 5 versus 20 mg: 0.7, upper 2.8. Mean stools 10.7, 10.9, 10.8 (20,10,5 mg); reported differences 0.3 (upper 1.0) and 0.1 (upper 0.8). Indexed published version used; source-version differences retained in paper notes. [zn-clin-dhingra2020] Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. (2020). https://pubmed.ncbi.nlm.nih.gov/32966722/ DOI: 10.1056/nejmoa1915905
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.