Component
Dyspepsia-associated withdrawal in the Ceylon phase I study
Dyspepsia-associated withdrawal in the Ceylon phase I study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Two of 30 enrolled participants discontinued the phase I study because of dyspepsia.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ceylon-research/29282046.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9f042ba36cfd9e3e8a8e76e155c71d6b742c431c1ba4cf90c3a94115f3b06c61", "start_char": 0, "end_char": 2508, "text_sha256": "9f042ba36cfd9e3e8a8e76e155c71d6b742c431c1ba4cf90c3a94115f3b06c61"}
- experimental_model
- Uncontrolled phase I escalating-dose study
- exposure
- 30 enrolled, 28 completed; water extract 85, 250 and 500 mg at successive monthly intervals
- limitations
- No placebo group; three months and a small healthy sample cannot establish long-term safety or efficacy in disease.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Human
- plain_language
- Stomach discomfort was important enough for two people to stop.
- primary_references
- [ceylon-p29282046] Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. (2017). https://pubmed.ncbi.nlm.nih.gov/29282046/ DOI: 10.1186/s12906-017-2067-7
- tissue_or_cell_type
- Healthy adults, clinical and laboratory measures
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1117–1128
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Uncontrolled phase I escalating-dose study · source_derived_draft · unverified_draft
### ceylon-phase1-dyspepsia Two of 30 enrolled participants discontinued the phase I study because of dyspepsia. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Stomach discomfort was important enough for two people to stop. organism: Human tissue_or_cell_type: Healthy adults, clinical and laboratory measures experimental_model: Uncontrolled phase I escalating-dose study limitations: No placebo group; three months and a small healthy sample cannot establish long-term safety or efficacy in disease. exposure: 30 enrolled, 28 completed; water extract 85, 250 and 500 mg at successive monthly intervals evidence_span: {"source_cache": "artifacts/ceylon-research/29282046.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9f042ba36cfd9e3e8a8e76e155c71d6b742c431c1ba4cf90c3a94115f3b06c61", "start_char": 0, "end_char": 2508, "text_sha256": "9f042ba36cfd9e3e8a8e76e155c71d6b742c431c1ba4cf90c3a94115f3b06c61"} [ceylon-p29282046] Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. (2017). https://pubmed.ncbi.nlm.nih.gov/29282046/ DOI: 10.1186/s12906-017-2067-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.