Component
Cerebellar ataxia severity
Cerebellar ataxia severity. Read linked claims for the population, experiment and limits.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ataxia Rating Scale scores improved modestly but significantly after one year of vitamin E in the AVED cohort; results were better with shorter disease duration.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Uncontrolled one-year supplementation study; 24 genetically investigated AVED patients
- exposure
- Vitamin E 800 mg/day for one year; formulation stereochemistry not specified in the retrieved abstract.
- limitations
- Small uncontrolled genetic-disease cohort; no inference of complete reversal, a general population dose or isolated dietary deficiency.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- Treating the inherited vitamin E shortage modestly improved coordination in this study.
- primary_references
- [e-clin-aved2001] Effect of vitamin E supplementation in patients with ataxia with vitamin E deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11554913/ DOI: 10.1046/j.1468-1331.2001.00273.x
- tissue_or_cell_type
- Nervous system and serum
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1167–1178
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Uncontrolled one-year supplementation study; 24 genetically investigated AVED patients · source_derived_draft · unverified_draft
### e-clin-aved-ataxia Ataxia Rating Scale scores improved modestly but significantly after one year of vitamin E in the AVED cohort; results were better with shorter disease duration. Condition category: machinery_impairment nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Treating the inherited vitamin E shortage modestly improved coordination in this study. organism: Homo sapiens tissue_or_cell_type: Nervous system and serum experimental_model: Uncontrolled one-year supplementation study; 24 genetically investigated AVED patients limitations: Small uncontrolled genetic-disease cohort; no inference of complete reversal, a general population dose or isolated dietary deficiency. exposure: Vitamin E 800 mg/day for one year; formulation stereochemistry not specified in the retrieved abstract. cross_nutrient: false [e-clin-aved2001] Effect of vitamin E supplementation in patients with ataxia with vitamin E deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11554913/ DOI: 10.1046/j.1468-1331.2001.00273.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.