Component
Cellular magnesium content
Measured intracellular magnesium pool; assay-specific total versus free fractions remain distinct.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
TRPM7-deficient DT40 cells became magnesium depleted.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence-system
- Targeted gene disruption and Mg measurements in DT40 cells
- experimental_model
- Targeted gene disruption and Mg measurements in DT40 cells
- limitations
- Cell-line dependence does not establish universal necessity in every mammalian cell.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Chicken
- plain_language
- Loss of this entry channel reduced the cells magnesium supply.
- primary_references
- [schmitz-2003-trpm7] Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7 (2003). https://pubmed.ncbi.nlm.nih.gov/12887921/ DOI: 10.1016/S0092-8674(03)00556-7
- tissue
- B-cell line
- tissue_or_cell_type
- B-cell line
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 949–960
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted gene disruption and Mg measurements in DT40 cells · source_derived_draft · unverified_draft
### trpm7-loss-cellular-magnesium TRPM7-deficient DT40 cells became magnesium depleted. Condition category: machinery_impairment nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of this entry channel reduced the cells magnesium supply. organism: Chicken tissue_or_cell_type: B-cell line experimental_model: Targeted gene disruption and Mg measurements in DT40 cells limitations: Cell-line dependence does not establish universal necessity in every mammalian cell. evidence-system: Targeted gene disruption and Mg measurements in DT40 cells tissue: B-cell line [schmitz-2003-trpm7] Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7 (2003). https://pubmed.ncbi.nlm.nih.gov/12887921/ DOI: 10.1016/S0092-8674(03)00556-7
Complete structured claim and evidence
Where it participates (unsigned role)
Increasing extracellular Mg restored proliferation and viability of TRPM7-deficient DT40 cells.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence-system
- Extracellular magnesium supplementation after TRPM7 disruption
- experimental_model
- Extracellular magnesium supplementation after TRPM7 disruption
- limitations
- Culture rescue is not a clinical dose recommendation or evidence all TRPM7 functions are Mg-dependent.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Chicken
- plain_language
- Additional magnesium bypassed enough of the transport defect to restore cultured-cell growth.
- primary_references
- [schmitz-2003-trpm7] Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7 (2003). https://pubmed.ncbi.nlm.nih.gov/12887921/ DOI: 10.1016/S0092-8674(03)00556-7
- tissue
- DT40 B-cell culture
- tissue_or_cell_type
- DT40 B-cell culture
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 962–973
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Extracellular magnesium supplementation after TRPM7 disruption · source_derived_draft · unverified_draft
### magnesium-rescues-trpm7-cell-proliferation Increasing extracellular Mg restored proliferation and viability of TRPM7-deficient DT40 cells. Condition category: machinery_impairment nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Additional magnesium bypassed enough of the transport defect to restore cultured-cell growth. organism: Chicken tissue_or_cell_type: DT40 B-cell culture experimental_model: Extracellular magnesium supplementation after TRPM7 disruption limitations: Culture rescue is not a clinical dose recommendation or evidence all TRPM7 functions are Mg-dependent. evidence-system: Extracellular magnesium supplementation after TRPM7 disruption tissue: DT40 B-cell culture [schmitz-2003-trpm7] Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7 (2003). https://pubmed.ncbi.nlm.nih.gov/12887921/ DOI: 10.1016/S0092-8674(03)00556-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.