Component
Cell-cycle progression
Independent cellular process record; interpretation is limited by each linked claim and its study context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In noncancerous human cell lines, lysine withdrawal rapidly inhibited protein synthesis and stalled cell-cycle progression.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Live-cell imaging and perturbation experiments, primarily MCF10A and RPE-hTERT
- limitations
- Cell-line and acute-starvation context; response differs among amino acids and may vary across primary tissues.
- organism
- Homo sapiens
- plain_language
- Removing this required amino acid disrupted protein production and division in cultured cells.
- primary_references
- [rong2023] Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC11238304/ DOI: 10.1016/j.celrep.2023.113539
- tissue_or_cell_type
- Mammary epithelial and retinal pigment epithelial cell lines
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 829–837
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Live-cell imaging and perturbation experiments, primarily MCF10A and RPE-hTERT · source_derived_draft · unverified_draft
### lysine-deprivation-cellcycle In noncancerous human cell lines, lysine withdrawal rapidly inhibited protein synthesis and stalled cell-cycle progression. Plain language: Removing this required amino acid disrupted protein production and division in cultured cells. Condition category: nutrient_deficiency organism: Homo sapiens tissue_or_cell_type: Mammary epithelial and retinal pigment epithelial cell lines experimental_model: Live-cell imaging and perturbation experiments, primarily MCF10A and RPE-hTERT limitations: Cell-line and acute-starvation context; response differs among amino acids and may vary across primary tissues. [rong2023] Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC11238304/ DOI: 10.1016/j.celrep.2023.113539
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.