Component
CDK5 p25/p35 tau-kinase axis
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Annonacin exposure produced greater tau accumulation, phosphorylation and redistribution in R406W-MAPT transgenic mice than in mice with endogenous mouse tau.
Experimental context and source evidence
- dose
- Experimental annonacin exposure
- duration
- Study interval specified in the primary article
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- R406W-MAPT transgenic and non-transgenic mice
- limitations
- Gene-environment interaction in a transgenic model does not establish penetrance or dose-response in humans.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- R406W-MAPT transgenic and non-transgenic mice
- plain_language
- Annonacin exposure produced greater tau accumulation, phosphorylation and redistribution in R406W-MAPT transgenic mice than in mice with endogenous mouse tau.
- primary_references
- Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. (2014). https://pubmed.ncbi.nlm.nih.gov/24389273/ DOI: 10.1016/j.expneurol.2013.12.017
- route
- In vivo mouse exposure
- tissue
- Tau abundance, phosphorylation, localization and proteasomal activity
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 66–75
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · R406W-MAPT transgenic and non-transgenic mice · source_derived_draft · unverified_draft
## graviola-r406w-synergy Annonacin exposure produced greater tau accumulation, phosphorylation and redistribution in R406W-MAPT transgenic mice than in mice with endogenous mouse tau. Model/species: R406W-MAPT transgenic and non-transgenic mice Tissue/system: Tau abundance, phosphorylation, localization and proteasomal activity Exposure: Experimental annonacin exposure Route: In vivo mouse exposure Duration: Study interval specified in the primary article Limits: Gene-environment interaction in a transgenic model does not establish penetrance or dose-response in humans. Primary reference: Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. (2014). https://pubmed.ncbi.nlm.nih.gov/24389273/ DOI: 10.1016/j.expneurol.2013.12.017 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.