Component
The CB2 receptor in complex with heterotrimeric Gi
The CB2 receptor in complex with heterotrimeric Gi. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The cryo-EM structure of the human CB2 receptor in complex with Gi resolved the active-state signalling complex.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/32004460.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92", "start_char": 0, "end_char": 885, "text_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92"}
- experimental_model
- Cryo-electron microscopy of the CB2 receptor bound to heterotrimeric Gi
- exposure
- Agonist-bound receptor coupled to Gi
- limitations
- Captures the active, G-protein-coupled state rather than an antagonist-bound one, which is what makes the coupling claim structural rather than inferred.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Human receptor complex
- plain_language
- The receptor was caught in the act of holding its signalling partner.
- primary_references
- [thc-p32004460] Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. (2020). https://pubmed.ncbi.nlm.nih.gov/32004460/ DOI: 10.1016/j.cell.2020.01.007
- tissue_or_cell_type
- Purified signalling complex
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 140–151
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-electron microscopy of the CB2 receptor bound to heterotrimeric Gi · source_derived_draft · unverified_draft
### thc-cb2-gi-structure The cryo-EM structure of the human CB2 receptor in complex with Gi resolved the active-state signalling complex. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor was caught in the act of holding its signalling partner. organism: Human receptor complex tissue_or_cell_type: Purified signalling complex experimental_model: Cryo-electron microscopy of the CB2 receptor bound to heterotrimeric Gi limitations: Captures the active, G-protein-coupled state rather than an antagonist-bound one, which is what makes the coupling claim structural rather than inferred. exposure: Agonist-bound receptor coupled to Gi evidence_span: {"source_cache": "artifacts/thc-research/32004460.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92", "start_char": 0, "end_char": 885, "text_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92"} [thc-p32004460] Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. (2020). https://pubmed.ncbi.nlm.nih.gov/32004460/ DOI: 10.1016/j.cell.2020.01.007
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.