Component
N-type voltage-gated calcium channel Cav2.2
N-type voltage-gated calcium channel Cav2.2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
CB1 controls GABA release by inhibiting calcium entry into presynaptic axon terminals via N-type Cav2.2 channels, with a power relationship of exponent 2.2 between unitary inhibitory current amplitude and intrabouton calcium.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/24899717.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "037d9888adff577901a9dc0d0cd27fdb4fd755da283857a848a15484dd53d2ed", "start_char": 0, "end_char": 1204, "text_sha256": "037d9888adff577901a9dc0d0cd27fdb4fd755da283857a848a15484dd53d2ed"}
- experimental_model
- Paired recordings and presynaptic calcium imaging in mouse hippocampal slices
- exposure
- CB1 activation and removal of tonic activity at interneuron-pyramidal cell connections
- limitations
- Identifies the specific channel and gives the power relationship between calcium and release. It concerns inhibitory terminals of one interneuron class.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Mouse
- plain_language
- The receptor works by closing the calcium gate that triggers transmitter release.
- primary_references
- [thc-p24899717] Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release. (2014). https://pubmed.ncbi.nlm.nih.gov/24899717/ DOI: 10.1523/jneurosci.0247-14.2014
- tissue_or_cell_type
- Hippocampus
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 192–203
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired recordings and presynaptic calcium imaging in mouse hippocampal slices · source_derived_draft · unverified_draft
### thc-cb1-calcium-channel CB1 controls GABA release by inhibiting calcium entry into presynaptic axon terminals via N-type Cav2.2 channels, with a power relationship of exponent 2.2 between unitary inhibitory current amplitude and intrabouton calcium. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor works by closing the calcium gate that triggers transmitter release. organism: Mouse tissue_or_cell_type: Hippocampus experimental_model: Paired recordings and presynaptic calcium imaging in mouse hippocampal slices limitations: Identifies the specific channel and gives the power relationship between calcium and release. It concerns inhibitory terminals of one interneuron class. exposure: CB1 activation and removal of tonic activity at interneuron-pyramidal cell connections evidence_span: {"source_cache": "artifacts/thc-research/24899717.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "037d9888adff577901a9dc0d0cd27fdb4fd755da283857a848a15484dd53d2ed", "start_char": 0, "end_char": 1204, "text_sha256": "037d9888adff577901a9dc0d0cd27fdb4fd755da283857a848a15484dd53d2ed"} [thc-p24899717] Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release. (2014). https://pubmed.ncbi.nlm.nih.gov/24899717/ DOI: 10.1523/jneurosci.0247-14.2014
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.