Component

Cardiac magnesium-inhibited cation current

Cardiac magnesium-inhibited cation current. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Hydrolyzable ATP supported maintenance of cardiac magnesium-inhibited cation current, whereas a nonhydrolyzable ATP analog did not substitute.

    ATP → Cardiac magnesium-inhibited cation current source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/inositol-research/16707555.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef", "start_char": 0, "end_char": 1640, "text_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef"}
    experimental_model
    Cardiac patch clamp and lipid/ATP manipulation
    exposure
    ATP withdrawal, analogs and exogenous PIP2
    limitations
    The current was described as TRPM7-like; this experiment alone does not establish its molecular identity.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Pig, rat and guinea pig cardiac cells
    plain_language
    ATP had to support a chemical reaction, rather than merely occupy a binding site.
    primary_references
    [ino-p16707555] ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. (2006). https://pubmed.ncbi.nlm.nih.gov/16707555/ DOI: 10.1152/ajpcell.00074.2006
    tissue_or_cell_type
    Cardiac magnesium-inhibited current
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 990–1001

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cardiac patch clamp and lipid/ATP manipulation · source_derived_draft · unverified_draft

    ### ino-mic-atp Hydrolyzable ATP supported maintenance of cardiac magnesium-inhibited cation current, whereas a nonhydrolyzable ATP analog did not substitute. Condition category: machinery_impairment nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: ATP had to support a chemical reaction, rather than merely occupy a binding site. organism: Pig, rat and guinea pig cardiac cells tissue_or_cell_type: Cardiac magnesium-inhibited current experimental_model: Cardiac patch clamp and lipid/ATP manipulation limitations: The current was described as TRPM7-like; this experiment alone does not establish its molecular identity. exposure: ATP withdrawal, analogs and exogenous PIP2 evidence_span: {"source_cache": "artifacts/inositol-research/16707555.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef", "start_char": 0, "end_char": 1640, "text_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef"} [ino-p16707555] ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. (2006). https://pubmed.ncbi.nlm.nih.gov/16707555/ DOI: 10.1152/ajpcell.00074.2006
    Complete structured claim and evidence

  2. Exogenous PIP2 restored cardiac MIC current after rundown in ATP-depleted conditions.

    Phosphatidylinositol 4,5-bisphosphate → Cardiac magnesium-inhibited cation current source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/inositol-research/16707555.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef", "start_char": 0, "end_char": 1640, "text_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef"}
    experimental_model
    Cardiac patch clamp and lipid/ATP manipulation
    exposure
    ATP withdrawal, analogs and exogenous PIP2
    limitations
    The current was described as TRPM7-like; this experiment alone does not establish its molecular identity.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Pig, rat and guinea pig cardiac cells
    plain_language
    Restoring the membrane signal bypassed one consequence of ATP depletion in this assay.
    primary_references
    [ino-p16707555] ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. (2006). https://pubmed.ncbi.nlm.nih.gov/16707555/ DOI: 10.1152/ajpcell.00074.2006
    tissue_or_cell_type
    Cardiac magnesium-inhibited current
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1003–1014

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cardiac patch clamp and lipid/ATP manipulation · source_derived_draft · unverified_draft

    ### ino-mic-pip2-rescue Exogenous PIP2 restored cardiac MIC current after rundown in ATP-depleted conditions. Condition category: machinery_impairment nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Restoring the membrane signal bypassed one consequence of ATP depletion in this assay. organism: Pig, rat and guinea pig cardiac cells tissue_or_cell_type: Cardiac magnesium-inhibited current experimental_model: Cardiac patch clamp and lipid/ATP manipulation limitations: The current was described as TRPM7-like; this experiment alone does not establish its molecular identity. exposure: ATP withdrawal, analogs and exogenous PIP2 evidence_span: {"source_cache": "artifacts/inositol-research/16707555.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef", "start_char": 0, "end_char": 1640, "text_sha256": "b411ec23aa4b3ee2a861a8a9a99811acb039a03c18015a5954a1f90971d175ef"} [ino-p16707555] ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. (2006). https://pubmed.ncbi.nlm.nih.gov/16707555/ DOI: 10.1152/ajpcell.00074.2006
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards