Component
Calcitriol catabolism
Enzymatic oxidation and subsequent metabolism of 1alpha,25-dihydroxyvitamin D3.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Patient-derived CYP24A1 variants severely impaired calcitriol catabolism in expression assays; L409S retained 5.3% of wild-type activity in the detailed results.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary Results, in-vitro analysis and Figure 4; clinical cohorts and Discussion.
- experimental_model
- Patient variants expressed in V79-4 cells
- exposure
- Transient/stable transfection; calcitriol 0.003-9 micromolar depending on system.
- limitations
- The full text qualifies its abstract: L409S retained small measurable activity, so not all variants were absolutely inactive.
- nutrient
- Vitamin D2 and D3 · Vitamin D2 and D3
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens protein in hamster-derived cells
- plain_language
- Some inherited defects prevent normal removal of active vitamin D.
- primary_references
- [schlingmann2011] Mutations in CYP24A1 and idiopathic infantile hypercalcemia. (2011). https://pubmed.ncbi.nlm.nih.gov/21675912/ DOI: 10.1056/NEJMoa1103864
- tissue_or_cell_type
- cellular catabolic assay
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 587–600
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Patient variants expressed in V79-4 cells · source_derived_draft · unverified_draft
### vd-act-cyp24a1-loss Patient-derived CYP24A1 variants severely impaired calcitriol catabolism in expression assays; L409S retained 5.3% of wild-type activity in the detailed results. Condition category: machinery_impairment nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Some inherited defects prevent normal removal of active vitamin D. organism: Homo sapiens protein in hamster-derived cells tissue_or_cell_type: cellular catabolic assay experimental_model: Patient variants expressed in V79-4 cells limitations: The full text qualifies its abstract: L409S retained small measurable activity, so not all variants were absolutely inactive. exposure: Transient/stable transfection; calcitriol 0.003-9 micromolar depending on system. cross_nutrient: false evidence_location: Primary Results, in-vitro analysis and Figure 4; clinical cohorts and Discussion. nutrient: Vitamin D2 and D3 [schlingmann2011] Mutations in CYP24A1 and idiopathic infantile hypercalcemia. (2011). https://pubmed.ncbi.nlm.nih.gov/21675912/ DOI: 10.1056/NEJMoa1103864
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.