Component

Caffeine elimination half-life

Study-scoped entity; inspect species, exposure, model and limitations on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Women using oral contraceptives had caffeine half-life 10.7 versus 6.2 hours and lower clearance than women not using them.

    Oral contraceptive steroids, study-specific formulations → Caffeine elimination half-life source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    250 mg caffeine; nine women per female group and 13 men; historical formulations.
    limitations
    Between-group study and formulation-specific context; no universal effect size for all contraceptives.
    nutrient_topic
    Caffeine collection; salts, coffee, species and coexposure contexts retain their identities. · Caffeine
    plain_language
    Hormonal medication changed caffeine persistence.
    primary_references
    Impaired elimination of caffeine by oral contraceptive steroids. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7359014/

    Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18) · lines 252–258

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · 250 mg caffeine; nine women per female group and 13 men; historical formulations. · source_derived_draft · unverified_draft

    ## caf-contraceptive Hormonal medication changed caffeine persistence. Women using oral contraceptives had caffeine half-life 10.7 versus 6.2 hours and lower clearance than women not using them. Model: 250 mg caffeine; nine women per female group and 13 men; historical formulations. Limitations: Between-group study and formulation-specific context; no universal effect size for all contraceptives. Evidence access: Primary abstract Impaired elimination of caffeine by oral contraceptive steroids. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7359014/
    Complete structured claim and evidence

  2. Caffeine half-life increased from five to 31 hours in the fluvoxamine crossover experiment.

    Fluvoxamine → Caffeine elimination half-life source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.
    limitations
    Reported median under this regimen, not a universal caffeine half-life.
    nutrient_topic
    Caffeine collection; salts, coffee, species and coexposure contexts retain their identities. · Caffeine
    plain_language
    The same dose remained in the body much longer.
    primary_references
    A fluvoxamine-caffeine interaction study. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8807660/ · DOI 10.1097/00008571-199606000-00003

    Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18) · lines 204–210

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers. · source_derived_draft · unverified_draft

    ## caf-fluvox-half The same dose remained in the body much longer. Caffeine half-life increased from five to 31 hours in the fluvoxamine crossover experiment. Model: Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers. Limitations: Reported median under this regimen, not a universal caffeine half-life. Evidence access: Primary abstract A fluvoxamine-caffeine interaction study. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8807660/ · DOI 10.1097/00008571-199606000-00003
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards