Component
Clostridioides difficile aromatic amino-acid ABC transport system
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Loss of two C. difficile ABC-transporter genes was associated with lower tyrosine/phenylalanine uptake and p-cresol production, without a measurable growth or enterotoxin effect.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Genomic and phenotypic strain comparisons; convergent loss and laboratory emergence.
- limitations
- Association is retained as such; this is not direct human host transporter evidence.
- nutrient_topic
- L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Tyrosine
- plain_language
- Microbial access to a nutrient can change its products without stopping growth.
- primary_references
- Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29867812/ · DOI 10.3389/fmicb.2018.00901
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19) · lines 364–370
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Genomic and phenotypic strain comparisons; convergent loss and laboratory emergence. · source_derived_draft · unverified_draft
## l-tyrosine-bacterial-import Microbial access to a nutrient can change its products without stopping growth. Loss of two C. difficile ABC-transporter genes was associated with lower tyrosine/phenylalanine uptake and p-cresol production, without a measurable growth or enterotoxin effect. Model: Genomic and phenotypic strain comparisons; convergent loss and laboratory emergence. Limitations: Association is retained as such; this is not direct human host transporter evidence. Evidence access: Primary abstract Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29867812/ · DOI 10.3389/fmicb.2018.00901
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.