Butyryl-CoA: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

Butyryl-CoA:acetate CoA-transferase activity was detected in all 38 human-fecal butyrate-producing isolates examined, supporting this terminal route to butyrate.
Bacterial butyryl-CoA:acetate-CoA transferases → Butyrate source_derived_draftungraded
Experimental context and source evidence
evidence_access
Primary abstract
experimental_model
Anaerobic human-fecal isolates; enzyme assays and gene analysis.
limitations
A defined isolate panel is not a census of every human microbiome.
nutrient_topic
Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
plain_language
Many tested gut bacteria used acetate-linked CoA transfer to finish butyrate synthesis.
primary_references
Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15028695/ · DOI 10.1128/JB.186.7.2099-2106.2004
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 38–44
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Anaerobic human-fecal isolates; enzyme assays and gene analysis. · source_derived_draft · unverified_draft
## butyrate-coa-transferase-route Many tested gut bacteria used acetate-linked CoA transfer to finish butyrate synthesis. Butyryl-CoA:acetate CoA-transferase activity was detected in all 38 human-fecal butyrate-producing isolates examined, supporting this terminal route to butyrate. Model: Anaerobic human-fecal isolates; enzyme assays and gene analysis. Limitations: A defined isolate panel is not a census of every human microbiome. Evidence access: Primary abstract Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15028695/ · DOI 10.1128/JB.186.7.2099-2106.2004
Complete structured claim and evidence
Only four of 38 examined butyrate-producing isolates had detectable butyrate-kinase activity; the alternative terminal pathway includes phosphotransbutyrylase and butyrate kinase.
Bacterial butyrate kinases → Butyrate source_derived_draftungraded
Experimental context and source evidence
evidence_access
Primary abstract
experimental_model
Human-fecal anaerobic isolates, activity assays and PCR.
limitations
Do not assign the kinase route to every producer.
nutrient_topic
Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
plain_language
A second route existed but was less widespread in this isolate panel.
primary_references
Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15028695/ · DOI 10.1128/JB.186.7.2099-2106.2004
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 46–52
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human-fecal anaerobic isolates, activity assays and PCR. · source_derived_draft · unverified_draft
## butyrate-kinase-route A second route existed but was less widespread in this isolate panel. Only four of 38 examined butyrate-producing isolates had detectable butyrate-kinase activity; the alternative terminal pathway includes phosphotransbutyrylase and butyrate kinase. Model: Human-fecal anaerobic isolates, activity assays and PCR. Limitations: Do not assign the kinase route to every producer. Evidence access: Primary abstract Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15028695/ · DOI 10.1128/JB.186.7.2099-2106.2004
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Butyryl-CoA