Component
Brequinar
Brequinar. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The 2023 study attributed strong ferroptosis sensitization by high concentrations of DHODH inhibitors to concurrent FSP1 inhibition.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/37407687.publisher-preview.txt", "locator": "Primary public publisher preview, reference superscripts removed; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dd04682c5ac5215eff4a195cf2fcff7c5f6cf59eb659cc5710e6a2ecd09b0529", "start_char": 0, "end_char": 477, "text_sha256": "dd04682c5ac5215eff4a195cf2fcff7c5f6cf59eb659cc5710e6a2ecd09b0529"}
- experimental_model
- Primary experimental Matters Arising; public publisher preview
- exposure
- DHODH inhibitors at different concentrations
- limitations
- Public preview only; exact dose-response tables not extracted. Do not deny all DHODH effects or invent a universal concentration cutoff.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Cancer-cell inhibitor and genetic comparisons
- plain_language
- A drug can affect a second enzyme, changing the explanation of its result.
- primary_references
- [coq10-p37407687] DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. (2023). https://pubmed.ncbi.nlm.nih.gov/37407687/ DOI: 10.1038/s41586-023-06269-0
- tissue_or_cell_type
- DHODH versus FSP1 attribution
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 840–851
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary experimental Matters Arising; public publisher preview · source_derived_draft · unverified_draft
### coq10-dhodh-offtarget The 2023 study attributed strong ferroptosis sensitization by high concentrations of DHODH inhibitors to concurrent FSP1 inhibition. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A drug can affect a second enzyme, changing the explanation of its result. organism: Cancer-cell inhibitor and genetic comparisons tissue_or_cell_type: DHODH versus FSP1 attribution experimental_model: Primary experimental Matters Arising; public publisher preview limitations: Public preview only; exact dose-response tables not extracted. Do not deny all DHODH effects or invent a universal concentration cutoff. exposure: DHODH inhibitors at different concentrations evidence_span: {"source_cache": "artifacts/coq10-research/37407687.publisher-preview.txt", "locator": "Primary public publisher preview, reference superscripts removed; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dd04682c5ac5215eff4a195cf2fcff7c5f6cf59eb659cc5710e6a2ecd09b0529", "start_char": 0, "end_char": 477, "text_sha256": "dd04682c5ac5215eff4a195cf2fcff7c5f6cf59eb659cc5710e6a2ecd09b0529"} [coq10-p37407687] DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. (2023). https://pubmed.ncbi.nlm.nih.gov/37407687/ DOI: 10.1038/s41586-023-06269-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.