Component

Boron complex with NAD+

Boron complex with NAD+. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Boron binding in the tested nucleotide series depended on suitable cis-diol groups, and NAD+ bound more strongly than NADH in the capillary-electrophoresis assay.

    NAD+ → Boron complex with NAD+ source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/11420139.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0792ce09223d7cf23f0d3fda6b793e6e3b9904abe2c1f934b96d50e3a0e8b703", "start_char": 0, "end_char": 1650, "text_sha256": "0792ce09223d7cf23f0d3fda6b793e6e3b9904abe2c1f934b96d50e3a0e8b703"}
    experimental_model
    Capillary electrophoresis of purified metabolites
    exposure
    Boron complexation under the reported assay conditions
    limitations
    Chemical affinity is not a demonstrated metabolic function or in-vivo occupancy. Rankings depend on assay and solution conditions.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Cell-free chemistry
    plain_language
    The arrangement of neighboring hydroxyl groups helps determine which nucleotide molecules can bind boron.
    primary_references
    [boron-p11420139] Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis. (2001). https://pubmed.ncbi.nlm.nih.gov/11420139/ DOI: 10.1016/s0304-4165(01)00130-1
    tissue_or_cell_type
    Aqueous assay; no tissue

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 105–116

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Capillary electrophoresis of purified metabolites · source_derived_draft · unverified_draft

    ### boron-cis-diol-binding Boron binding in the tested nucleotide series depended on suitable cis-diol groups, and NAD+ bound more strongly than NADH in the capillary-electrophoresis assay. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The arrangement of neighboring hydroxyl groups helps determine which nucleotide molecules can bind boron. organism: Cell-free chemistry tissue_or_cell_type: Aqueous assay; no tissue experimental_model: Capillary electrophoresis of purified metabolites limitations: Chemical affinity is not a demonstrated metabolic function or in-vivo occupancy. Rankings depend on assay and solution conditions. exposure: Boron complexation under the reported assay conditions evidence_span: {"source_cache": "artifacts/boron-research/11420139.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0792ce09223d7cf23f0d3fda6b793e6e3b9904abe2c1f934b96d50e3a0e8b703", "start_char": 0, "end_char": 1650, "text_sha256": "0792ce09223d7cf23f0d3fda6b793e6e3b9904abe2c1f934b96d50e3a0e8b703"} [boron-p11420139] Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis. (2001). https://pubmed.ncbi.nlm.nih.gov/11420139/ DOI: 10.1016/s0304-4165(01)00130-1
    Complete structured claim and evidence

  2. NAD+ formed monoester, diester and diborate adducts through ribose cis-2,3-diol groups rather than phosphate hydroxyls; the 1:1 monoester localized to the adenosine ribose.

    NAD+ → Boron complex with NAD+ source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/12827632.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a7c91724a5710f61e1907669a1137b421e1e13117ae707e567bd16ca0eea9ed6", "start_char": 0, "end_char": 1255, "text_sha256": "a7c91724a5710f61e1907669a1137b421e1e13117ae707e567bd16ca0eea9ed6"}
    experimental_model
    Electrospray mass spectrometry and boron-11 NMR
    exposure
    NAD+/NADH with boric acid or borate across pH conditions; complexes detected at 50 µM each at pH 7
    limitations
    Chemical structure experiments do not establish cellular concentrations or physiological consequences.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Cell-free chemistry
    plain_language
    Boron attaches to the sugar portion of NAD+ in these experiments.
    primary_references
    [boron-p12827632] Esterification of borate with NAD+ and NADH as studied by electrospray ionization mass spectrometry and 11B NMR spectroscopy. (2003). https://pubmed.ncbi.nlm.nih.gov/12827632/ DOI: 10.1002/jms.476
    tissue_or_cell_type
    Purified nucleotide solutions

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 118–129

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Electrospray mass spectrometry and boron-11 NMR · source_derived_draft · unverified_draft

    ### boron-nad-adduct-structure NAD+ formed monoester, diester and diborate adducts through ribose cis-2,3-diol groups rather than phosphate hydroxyls; the 1:1 monoester localized to the adenosine ribose. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Boron attaches to the sugar portion of NAD+ in these experiments. organism: Cell-free chemistry tissue_or_cell_type: Purified nucleotide solutions experimental_model: Electrospray mass spectrometry and boron-11 NMR limitations: Chemical structure experiments do not establish cellular concentrations or physiological consequences. exposure: NAD+/NADH with boric acid or borate across pH conditions; complexes detected at 50 µM each at pH 7 evidence_span: {"source_cache": "artifacts/boron-research/12827632.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a7c91724a5710f61e1907669a1137b421e1e13117ae707e567bd16ca0eea9ed6", "start_char": 0, "end_char": 1255, "text_sha256": "a7c91724a5710f61e1907669a1137b421e1e13117ae707e567bd16ca0eea9ed6"} [boron-p12827632] Esterification of borate with NAD+ and NADH as studied by electrospray ionization mass spectrometry and 11B NMR spectroscopy. (2003). https://pubmed.ncbi.nlm.nih.gov/12827632/ DOI: 10.1002/jms.476
    Complete structured claim and evidence

  3. The reported boron-binding order was NAD+ > NADH > NADP+ > NADPH at pH 10.3; only the NAD+ complex was observed in the separate pH 7.4 ammonium-bicarbonate condition.

    NAD+ → Boron complex with NAD+ source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/15282753.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9385dca91d3dc7bb5a3d2a9c71a8e4c4ec0af136a15de2ea9536365a048d8057", "start_char": 0, "end_char": 1378, "text_sha256": "9385dca91d3dc7bb5a3d2a9c71a8e4c4ec0af136a15de2ea9536365a048d8057"}
    experimental_model
    Electrospray mass spectrometry comparing nucleotide binding
    exposure
    100 µM nucleotide and 500 µM boric acid in WAT solvent at pH 10.3; separate pH 7.4 ammonium bicarbonate condition
    limitations
    Relative ion signals and assay-specific rankings cannot be treated as universal binding constants or in-vivo metabolic effects.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Cell-free chemistry
    plain_language
    Added phosphate groups and the test solution change the observed binding pattern.
    primary_references
    [boron-p15282753] Borate-nucleotide complex formation depends on charge and phosphorylation state. (2004). https://pubmed.ncbi.nlm.nih.gov/15282753/ DOI: 10.1002/jms.645
    tissue_or_cell_type
    Purified nucleotide solutions

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 144–155

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Electrospray mass spectrometry comparing nucleotide binding · source_derived_draft · unverified_draft

    ### boron-nad-phosphate-context The reported boron-binding order was NAD+ > NADH > NADP+ > NADPH at pH 10.3; only the NAD+ complex was observed in the separate pH 7.4 ammonium-bicarbonate condition. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Added phosphate groups and the test solution change the observed binding pattern. organism: Cell-free chemistry tissue_or_cell_type: Purified nucleotide solutions experimental_model: Electrospray mass spectrometry comparing nucleotide binding limitations: Relative ion signals and assay-specific rankings cannot be treated as universal binding constants or in-vivo metabolic effects. exposure: 100 µM nucleotide and 500 µM boric acid in WAT solvent at pH 10.3; separate pH 7.4 ammonium bicarbonate condition evidence_span: {"source_cache": "artifacts/boron-research/15282753.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9385dca91d3dc7bb5a3d2a9c71a8e4c4ec0af136a15de2ea9536365a048d8057", "start_char": 0, "end_char": 1378, "text_sha256": "9385dca91d3dc7bb5a3d2a9c71a8e4c4ec0af136a15de2ea9536365a048d8057"} [boron-p15282753] Borate-nucleotide complex formation depends on charge and phosphorylation state. (2004). https://pubmed.ncbi.nlm.nih.gov/15282753/ DOI: 10.1002/jms.645
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards