Component
Molecular and behavioural tolerance to alcohol at the BK channel
Molecular and behavioural tolerance to alcohol at the BK channel. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A BK channel auxiliary protein was identified that controls molecular and behavioural tolerance to alcohol.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/18981408.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e67be69c00867e16027760fe3f5f6818d63da287c671683b2f83e57b6fae434d", "start_char": 0, "end_char": 1596, "text_sha256": "e67be69c00867e16027760fe3f5f6818d63da287c671683b2f83e57b6fae434d"}
- experimental_model
- Identification of a BK auxiliary subunit controlling tolerance, with behavioural testing
- exposure
- Repeated alcohol exposure with and without the auxiliary subunit
- limitations
- Connects a molecular tolerance mechanism to behaviour. The auxiliary subunit work spans model systems, so the mapping to human tolerance is indirect.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Invertebrate and mammalian systems
- plain_language
- A helper subunit decides whether repeated drinking makes the channel stop responding.
- primary_references
- [alcohol-p18981408] Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. (2008). https://pubmed.ncbi.nlm.nih.gov/18981408/ DOI: 10.1073/pnas.0801068105
- tissue_or_cell_type
- BK channel complexes
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 371–382
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Identification of a BK auxiliary subunit controlling tolerance, with behavioural testing · source_derived_draft · unverified_draft
### alcohol-bk-beta4-tolerance A BK channel auxiliary protein was identified that controls molecular and behavioural tolerance to alcohol. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: A helper subunit decides whether repeated drinking makes the channel stop responding. organism: Invertebrate and mammalian systems tissue_or_cell_type: BK channel complexes experimental_model: Identification of a BK auxiliary subunit controlling tolerance, with behavioural testing limitations: Connects a molecular tolerance mechanism to behaviour. The auxiliary subunit work spans model systems, so the mapping to human tolerance is indirect. exposure: Repeated alcohol exposure with and without the auxiliary subunit evidence_span: {"source_cache": "artifacts/alcohol-research/18981408.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e67be69c00867e16027760fe3f5f6818d63da287c671683b2f83e57b6fae434d", "start_char": 0, "end_char": 1596, "text_sha256": "e67be69c00867e16027760fe3f5f6818d63da287c671683b2f83e57b6fae434d"} [alcohol-p18981408] Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. (2008). https://pubmed.ncbi.nlm.nih.gov/18981408/ DOI: 10.1073/pnas.0801068105
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.