Component
Bicuculline
Bicuculline. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Bicuculline prevented theanine-associated protection in the mouse ischemia model.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"}
- experimental_model
- Focal cerebral ischemia and pharmacological pathway blockade
- exposure
- Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid
- limitations
- Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors.
- nutrient_topic
- L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
- organism
- Mice
- plain_language
- The receptor mattered to this response, but the experiment did not establish direct receptor agonism.
- primary_references
- [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
- tissue_or_cell_type
- Cerebral infarct size at 24 hours
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 445–456
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Focal cerebral ischemia and pharmacological pathway blockade · source_derived_draft · unverified_draft
### theanine-gaba-a-blockade Bicuculline prevented theanine-associated protection in the mouse ischemia model. Condition category: machinery_impairment nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor mattered to this response, but the experiment did not establish direct receptor agonism. organism: Mice tissue_or_cell_type: Cerebral infarct size at 24 hours experimental_model: Focal cerebral ischemia and pharmacological pathway blockade limitations: Preclinical acute brain injury, not human stroke treatment or proof theanine directly activates GABA-A receptors. exposure: Theanine 1 mg/kg; four-hour MCA occlusion; bicuculline or 3-mercaptopropionic acid evidence_span: {"source_cache": "artifacts/theanine-research/17928735.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3", "start_char": 0, "end_char": 696, "text_sha256": "5568750575b7baedd13ae86dfa48298b5332447016c7b979f6fedf865ce00db3"} [theanine-p17928735] Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. (2007). https://pubmed.ncbi.nlm.nih.gov/17928735/ DOI: 10.1254/jphs.scz070901
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.