Component
Brown adipose tissue perfusion
Brown adipose tissue perfusion. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Cold induced a 12-fold increase in brown adipose tissue glucose uptake accompanied by a doubling of perfusion, with whole-body energy expenditure positively associated with perfusion, whereas insulin enhanced glucose uptake 5-fold independently of perfusion.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/21803297.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59c9610242aa276de795dd00e2855d10444505f6005a87b85bc058cd564a7e52", "start_char": 0, "end_char": 997, "text_sha256": "59c9610242aa276de795dd00e2855d10444505f6005a87b85bc058cd564a7e52"}
- experimental_model
- PET-CT of glucose uptake and perfusion in human brown and white adipose tissue with gene expression
- exposure
- Cold activation compared with insulin stimulation
- limitations
- The cold and insulin arms are separated deliberately, which shows the tissue has two distinct activation modes.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Human
- plain_language
- Cold makes the tissue take up fuel and open its blood supply; insulin only does the first.
- primary_references
- [cold-p21803297] Different metabolic responses of human brown adipose tissue to activation by cold and insulin. (2011). https://pubmed.ncbi.nlm.nih.gov/21803297/ DOI: 10.1016/j.cmet.2011.06.012
- tissue_or_cell_type
- Brown and white adipose tissue
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 299–310
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · PET-CT of glucose uptake and perfusion in human brown and white adipose tissue with gene expression · source_derived_draft · unverified_draft
### cold-bat-cold-versus-insulin Cold induced a 12-fold increase in brown adipose tissue glucose uptake accompanied by a doubling of perfusion, with whole-body energy expenditure positively associated with perfusion, whereas insulin enhanced glucose uptake 5-fold independently of perfusion. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Cold makes the tissue take up fuel and open its blood supply; insulin only does the first. organism: Human tissue_or_cell_type: Brown and white adipose tissue experimental_model: PET-CT of glucose uptake and perfusion in human brown and white adipose tissue with gene expression limitations: The cold and insulin arms are separated deliberately, which shows the tissue has two distinct activation modes. exposure: Cold activation compared with insulin stimulation evidence_span: {"source_cache": "artifacts/cold-research/21803297.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59c9610242aa276de795dd00e2855d10444505f6005a87b85bc058cd564a7e52", "start_char": 0, "end_char": 997, "text_sha256": "59c9610242aa276de795dd00e2855d10444505f6005a87b85bc058cd564a7e52"} [cold-p21803297] Different metabolic responses of human brown adipose tissue to activation by cold and insulin. (2011). https://pubmed.ncbi.nlm.nih.gov/21803297/ DOI: 10.1016/j.cmet.2011.06.012
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.