Component
Barium ion
Experimental ion-channel blocker; selectivity depends on concentration and preparation.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Luminal barium reduced potassium secretion by about 45% in the kidney-failure group, supporting a potassium-channel contribution.
Experimental context and source evidence
- experimental_model
- Rectal dialysis with 5 mmol/L barium.
- limitations
- Barium is not BK-specific; combine this with expression evidence without asserting exclusive BK mediation.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Homo sapiens
- plain_language
- Part of the extra gut potassium loss depended on a blocker-sensitive pathway.
- primary_references
- [k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750
- tissue_or_cell_type
- Human rectum
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1487–1496
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rectal dialysis with 5 mmol/L barium. · source_derived_draft · unverified_draft
### k-esrd-colonic-barium-sensitive-secretion Luminal barium reduced potassium secretion by about 45% in the kidney-failure group, supporting a potassium-channel contribution. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Part of the extra gut potassium loss depended on a blocker-sensitive pathway. organism: Homo sapiens tissue_or_cell_type: Human rectum experimental_model: Rectal dialysis with 5 mmol/L barium. limitations: Barium is not BK-specific; combine this with expression evidence without asserting exclusive BK mediation. [k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.