Component
ATP7B N-terminal metal-binding domain mobility
ATP7B N-terminal metal-binding domain mobility. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Copper transfer from ATOX1 reduced interactions within ATP7B MBD1-3 and increased domain mobility.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/28900031.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "64fceb98b5bf2ca406f26799cea5832b0306883118b9ad2416ba87db47b18ce8", "start_char": 0, "end_char": 1471, "text_sha256": "64fceb98b5bf2ca406f26799cea5832b0306883118b9ad2416ba87db47b18ce8"}
- experimental_model
- Biochemistry, solution NMR and small-angle X-ray scattering
- exposure
- Apo versus copper-loaded ATOX1
- limitations
- Domain motion and ATP hydrolysis were studied directly; these assays do not establish a whole-body copper requirement.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human proteins
- plain_language
- Copper handoff changes how the pump can move.
- primary_references
- [copper-p28900031] The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics. (2017). https://pubmed.ncbi.nlm.nih.gov/28900031/ DOI: 10.1074/jbc.m117.811752
- tissue_or_cell_type
- Purified ATOX1 and ATP7B domains
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 403–414
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemistry, solution NMR and small-angle X-ray scattering · source_derived_draft · unverified_draft
### copper-atox1-atp7b-mobility Copper transfer from ATOX1 reduced interactions within ATP7B MBD1-3 and increased domain mobility. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Copper handoff changes how the pump can move. organism: Human proteins tissue_or_cell_type: Purified ATOX1 and ATP7B domains experimental_model: Biochemistry, solution NMR and small-angle X-ray scattering limitations: Domain motion and ATP hydrolysis were studied directly; these assays do not establish a whole-body copper requirement. exposure: Apo versus copper-loaded ATOX1 evidence_span: {"source_cache": "artifacts/copper-research/28900031.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "64fceb98b5bf2ca406f26799cea5832b0306883118b9ad2416ba87db47b18ce8", "start_char": 0, "end_char": 1471, "text_sha256": "64fceb98b5bf2ca406f26799cea5832b0306883118b9ad2416ba87db47b18ce8"} [copper-p28900031] The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics. (2017). https://pubmed.ncbi.nlm.nih.gov/28900031/ DOI: 10.1074/jbc.m117.811752
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.