Component
AREDS2 lowest quintile of dietary lutein/zeaxanthin intake
AREDS2 lowest quintile of dietary lutein/zeaxanthin intake. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In the lowest dietary L+Z quintile, cataract-surgery HR was 0.68 (95% CI 0.48–0.96; P=0.03).
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/lutein-research/23645227.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3e75988c75dde9e6525246ae68335c49c03c31f02c7419dcf74110966b7dce32", "start_char": 0, "end_char": 2245, "text_sha256": "3e75988c75dde9e6525246ae68335c49c03c31f02c7419dcf74110966b7dce32"}
- experimental_model
- AREDS2 cataract secondary outcome and dietary subgroup analysis
- exposure
- L+Z 10/2 mg daily; median 4.7 years
- limitations
- Lowest-intake subgroup is not a clinical deficiency diagnosis; overall and subgroup results must stay separate.
- nutrient_topic
- Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
- organism
- 3159 participants phakic in at least one eye
- plain_language
- A subgroup with lower intake had a favorable estimate.
- primary_references
- [lutein-p23645227] Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4. (2013). https://pubmed.ncbi.nlm.nih.gov/23645227/ DOI: 10.1001/jamaophthalmol.2013.4412
- tissue_or_cell_type
- 6027 study eyes
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 827–838
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · AREDS2 cataract secondary outcome and dietary subgroup analysis · source_derived_draft · unverified_draft
### lutein-cataract-low-intake In the lowest dietary L+Z quintile, cataract-surgery HR was 0.68 (95% CI 0.48–0.96; P=0.03). Condition category: biomarker_context nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: A subgroup with lower intake had a favorable estimate. organism: 3159 participants phakic in at least one eye tissue_or_cell_type: 6027 study eyes experimental_model: AREDS2 cataract secondary outcome and dietary subgroup analysis limitations: Lowest-intake subgroup is not a clinical deficiency diagnosis; overall and subgroup results must stay separate. exposure: L+Z 10/2 mg daily; median 4.7 years evidence_span: {"source_cache": "artifacts/lutein-research/23645227.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3e75988c75dde9e6525246ae68335c49c03c31f02c7419dcf74110966b7dce32", "start_char": 0, "end_char": 2245, "text_sha256": "3e75988c75dde9e6525246ae68335c49c03c31f02c7419dcf74110966b7dce32"} [lutein-p23645227] Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4. (2013). https://pubmed.ncbi.nlm.nih.gov/23645227/ DOI: 10.1001/jamaophthalmol.2013.4412
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.