Component
Androgen receptor nuclear localization
Androgen receptor nuclear localization. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After treatment, 96% of evaluable patients showed androgen-receptor nuclear exclusion, compared with none in pretreatment biopsies.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/27069550.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e", "start_char": 0, "end_char": 1626, "text_sha256": "7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e"}
- experimental_model
- Pre-prostatectomy tissue and biomarker study
- exposure
- Absorption-enhanced DIM 225 mg twice daily for at least 14 days
- limitations
- Uncontrolled preoperative study. Tissue detection and altered localization do not establish tumor control, survival benefit or testosterone lowering.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- 28 evaluable men with localized prostate cancer
- plain_language
- A receptor changed location; this was not a randomized efficacy comparison.
- primary_references
- [dim-p27069550] Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients. (2016). https://pubmed.ncbi.nlm.nih.gov/27069550/
- tissue_or_cell_type
- Prostate DIM, androgen-receptor localization and PSA
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 1143–1154
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pre-prostatectomy tissue and biomarker study · source_derived_draft · unverified_draft
### dim-ar-exclusion After treatment, 96% of evaluable patients showed androgen-receptor nuclear exclusion, compared with none in pretreatment biopsies. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A receptor changed location; this was not a randomized efficacy comparison. organism: 28 evaluable men with localized prostate cancer tissue_or_cell_type: Prostate DIM, androgen-receptor localization and PSA experimental_model: Pre-prostatectomy tissue and biomarker study limitations: Uncontrolled preoperative study. Tissue detection and altered localization do not establish tumor control, survival benefit or testosterone lowering. exposure: Absorption-enhanced DIM 225 mg twice daily for at least 14 days evidence_span: {"source_cache": "artifacts/dim-research/27069550.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e", "start_char": 0, "end_char": 1626, "text_sha256": "7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e"} [dim-p27069550] Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients. (2016). https://pubmed.ncbi.nlm.nih.gov/27069550/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.