Component
Aplysia ADP-ribosyl cyclase
Aplysia ADP-ribosyl cyclase. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Boric acid inhibited purified Aplysia ADP-ribosyl cyclase noncompetitively with a reported Ki of 40.5 ± 0.5 mM.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/boron-research/16545389.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655", "start_char": 0, "end_char": 724, "text_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655"}
- experimental_model
- Purified Aplysia cyclase kinetics and electrospray complex analysis
- exposure
- Noncompetitive inhibition Ki 40.5 ± 0.5 mM boric acid; cADPR-binding assay pH 10.3
- limitations
- The enzyme was Aplysia cyclase, not human CD38. Millimolar enzyme inhibition and alkaline binding data do not establish effects of ordinary dietary boron.
- nutrient_topic
- Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
- organism
- Aplysia enzyme; cell-free chemistry
- plain_language
- High boric-acid concentrations slowed an enzyme that makes a calcium messenger; this was a sea-hare enzyme experiment.
- primary_references
- [boron-p16545389] Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively. (2006). https://pubmed.ncbi.nlm.nih.gov/16545389/ DOI: 10.1016/j.chroma.2006.02.066
- tissue_or_cell_type
- Purified enzyme and metabolites
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 157–168
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified Aplysia cyclase kinetics and electrospray complex analysis · source_derived_draft · unverified_draft
### boron-aplysia-cyclase-inhibition Boric acid inhibited purified Aplysia ADP-ribosyl cyclase noncompetitively with a reported Ki of 40.5 ± 0.5 mM. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: High boric-acid concentrations slowed an enzyme that makes a calcium messenger; this was a sea-hare enzyme experiment. organism: Aplysia enzyme; cell-free chemistry tissue_or_cell_type: Purified enzyme and metabolites experimental_model: Purified Aplysia cyclase kinetics and electrospray complex analysis limitations: The enzyme was Aplysia cyclase, not human CD38. Millimolar enzyme inhibition and alkaline binding data do not establish effects of ordinary dietary boron. exposure: Noncompetitive inhibition Ki 40.5 ± 0.5 mM boric acid; cADPR-binding assay pH 10.3 evidence_span: {"source_cache": "artifacts/boron-research/16545389.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655", "start_char": 0, "end_char": 724, "text_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655"} [boron-p16545389] Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively. (2006). https://pubmed.ncbi.nlm.nih.gov/16545389/ DOI: 10.1016/j.chroma.2006.02.066
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.