Component
Human AOX1 p.Gly1269Arg
Human AOX1 p.Gly1269Arg. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The inactive AOX1 G1269R crystal structure lacked the entire Moco cofactor.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/molybdenum-research/30985987.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5442ecc25ebcf48ef56cc840357bfe9f233c2c9738d5e6b685db86aed2249fe0", "start_char": 0, "end_char": 1497, "text_sha256": "5442ecc25ebcf48ef56cc840357bfe9f233c2c9738d5e6b685db86aed2249fe0"}
- experimental_model
- Human AOX1 variant crystallography and CD/ThermoFAD stability assays
- exposure
- Wild type compared with SNP variants
- limitations
- In-vitro structures and thermal stability; not physiological temperature or diet thresholds.
- nutrient_topic
- Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
- organism
- Homo sapiens protein
- plain_language
- Protein presence alone did not guarantee a working enzyme.
- primary_references
- [mo-p30985987] Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms. (2019). https://pubmed.ncbi.nlm.nih.gov/30985987/ DOI: 10.1002/2211-5463.12617
- tissue_or_cell_type
- Purified AOX1
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 872–883
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human AOX1 variant crystallography and CD/ThermoFAD stability assays · source_derived_draft · unverified_draft
### mo-aox-g1269r The inactive AOX1 G1269R crystal structure lacked the entire Moco cofactor. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: Protein presence alone did not guarantee a working enzyme. organism: Homo sapiens protein tissue_or_cell_type: Purified AOX1 experimental_model: Human AOX1 variant crystallography and CD/ThermoFAD stability assays limitations: In-vitro structures and thermal stability; not physiological temperature or diet thresholds. exposure: Wild type compared with SNP variants evidence_span: {"source_cache": "artifacts/molybdenum-research/30985987.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5442ecc25ebcf48ef56cc840357bfe9f233c2c9738d5e6b685db86aed2249fe0", "start_char": 0, "end_char": 1497, "text_sha256": "5442ecc25ebcf48ef56cc840357bfe9f233c2c9738d5e6b685db86aed2249fe0"} [mo-p30985987] Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms. (2019). https://pubmed.ncbi.nlm.nih.gov/30985987/ DOI: 10.1002/2211-5463.12617
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.