Component
Aortic pulse-wave velocity
Aortic pulse-wave velocity. The model and exposure of each linked claim define its scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The observed decrease in aortic pulse-wave velocity did not reach statistical significance after multiple-comparison correction; carotid compliance and brachial flow-mediated dilation showed no effect.
Experimental context and source evidence
- cross_nutrient
- Niacin precursor form and the measured endpoint are separate graph entities.
- evidence_span
- {"source_cache": "artifacts/niacin-clinical-sources/martens2018.txt", "locator": "Primary full report; exact character range, zero-based and end-exclusive", "file_sha256": "6743a5d9ad919ee67fb74af7f173b24bda66943d9c8878d6bc3bb72c80b2c37e", "start_char": 21021, "end_char": 21948, "text_sha256": "f7cee4adec07fb2c817d28092fb58a099173a569a7f20c6421687b8d995d31d2"}
- experimental_model
- Randomized double-blind crossover; 30 randomized, 24 healthy adults aged 55–79 completed
- exposure
- Nicotinamide riboside chloride 500 mg twice daily versus placebo, six weeks each
- limitations
- Small short trial, no formal washout, directional tests; secondary endpoints adjusted for multiple comparisons. PBMC NAD is not all-tissue NAD or evidence of lifespan extension.
- nutrient_topic
- Niacin research collection; topical membership is not evidence of a direct dietary effect. · Niacin (vitamin B3)
- organism
- Homo sapiens
- plain_language
- A higher blood NAD level was clearer than the exploratory vascular benefit in this trial.
- primary_references
- [nia-clin-martens2018] Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. (2018). https://pubmed.ncbi.nlm.nih.gov/29599478/ DOI: 10.1038/s41467-018-03421-7
- tissue_or_cell_type
- Peripheral blood mononuclear cells and vascular physiology
Niacin: NAD metabolism, deficiency and nutrient interactions (2026-09-17) · lines 1473–1485
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind crossover; 30 randomized, 24 healthy adults aged 55–79 completed · source_derived_draft · unverified_draft
### nia-clin-nr-vascular-bound The observed decrease in aortic pulse-wave velocity did not reach statistical significance after multiple-comparison correction; carotid compliance and brachial flow-mediated dilation showed no effect. Condition category: normal nutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A higher blood NAD level was clearer than the exploratory vascular benefit in this trial. organism: Homo sapiens tissue_or_cell_type: Peripheral blood mononuclear cells and vascular physiology experimental_model: Randomized double-blind crossover; 30 randomized, 24 healthy adults aged 55–79 completed limitations: Small short trial, no formal washout, directional tests; secondary endpoints adjusted for multiple comparisons. PBMC NAD is not all-tissue NAD or evidence of lifespan extension. exposure: Nicotinamide riboside chloride 500 mg twice daily versus placebo, six weeks each cross_nutrient: Niacin precursor form and the measured endpoint are separate graph entities. evidence_span: {"source_cache": "artifacts/niacin-clinical-sources/martens2018.txt", "locator": "Primary full report; exact character range, zero-based and end-exclusive", "file_sha256": "6743a5d9ad919ee67fb74af7f173b24bda66943d9c8878d6bc3bb72c80b2c37e", "start_char": 21021, "end_char": 21948, "text_sha256": "f7cee4adec07fb2c817d28092fb58a099173a569a7f20c6421687b8d995d31d2"} [nia-clin-martens2018] Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. (2018). https://pubmed.ncbi.nlm.nih.gov/29599478/ DOI: 10.1038/s41467-018-03421-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.