Component
Annonacin-associated neuronal tau redistribution and death
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Forced yeast NDI1 expression or stimulation of anaerobic glycolysis prevented annonacin-associated tau redistribution and neuronal death, whereas antioxidants did not.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Annonacin with NDI1 expression, glycolysis stimulation or antioxidants
- duration
- 48 hours
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Primary rat striatal neurons
- limitations
- NDI1 is an experimental bypass, and lack of antioxidant rescue does not exclude every redox contribution in vivo.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- Primary rat striatal neurons
- plain_language
- Forced yeast NDI1 expression or stimulation of anaerobic glycolysis prevented annonacin-associated tau redistribution and neuronal death, whereas antioxidants did not.
- primary_references
- Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. (2007). https://pubmed.ncbi.nlm.nih.gov/17634376/ DOI: 10.1523/JNEUROSCI.1644-07.2007
- route
- In vitro perturbation
- tissue
- Energy-pathway rescue and antioxidant controls
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 55–64
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Primary rat striatal neurons · source_derived_draft · unverified_draft
## graviola-ndi1-rescue Forced yeast NDI1 expression or stimulation of anaerobic glycolysis prevented annonacin-associated tau redistribution and neuronal death, whereas antioxidants did not. Model/species: Primary rat striatal neurons Tissue/system: Energy-pathway rescue and antioxidant controls Exposure: Annonacin with NDI1 expression, glycolysis stimulation or antioxidants Route: In vitro perturbation Duration: 48 hours Limits: NDI1 is an experimental bypass, and lack of antioxidant rescue does not exclude every redox contribution in vivo. Primary reference: Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. (2007). https://pubmed.ncbi.nlm.nih.gov/17634376/ DOI: 10.1523/JNEUROSCI.1644-07.2007 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.