Component
Alpha-linolenic acid (18:3)
Alpha-linolenic acid (18:3). Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Sham feeding emulsions containing oleic acid or linoleic acid caused a nearly twofold accumulation of jejunal endocannabinoids, whereas emulsions containing stearic acid or alpha-linolenic acid had no such effect, and corn oil raised them relative to mineral oil which contains no fatty acids.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/23463697.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079", "start_char": 0, "end_char": 1315, "text_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079"}
- experimental_model
- Sham-feeding protocol in rats with jejunal endocannabinoid measurement and peripheral CB1 antagonists
- exposure
- Sham feeding of defined fatty acid emulsions with peripherally restricted CB1 antagonists
- limitations
- Sham feeding separates oral exposure from absorption, and the peripherally restricted antagonists separate a gut mechanism from a brain one.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Rat
- plain_language
- Tasting certain fats, without swallowing them, makes the gut produce these messengers within minutes.
- primary_references
- [thc-p23463697] Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. (2013). https://pubmed.ncbi.nlm.nih.gov/23463697/ DOI: 10.1096/fj.13-227587
- tissue_or_cell_type
- Jejunum and behaviour
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 699–710
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sham-feeding protocol in rats with jejunal endocannabinoid measurement and peripheral CB1 antagonists · source_derived_draft · unverified_draft
### thc-fat-triggers-gut-endocannabinoids Sham feeding emulsions containing oleic acid or linoleic acid caused a nearly twofold accumulation of jejunal endocannabinoids, whereas emulsions containing stearic acid or alpha-linolenic acid had no such effect, and corn oil raised them relative to mineral oil which contains no fatty acids. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Tasting certain fats, without swallowing them, makes the gut produce these messengers within minutes. organism: Rat tissue_or_cell_type: Jejunum and behaviour experimental_model: Sham-feeding protocol in rats with jejunal endocannabinoid measurement and peripheral CB1 antagonists limitations: Sham feeding separates oral exposure from absorption, and the peripherally restricted antagonists separate a gut mechanism from a brain one. exposure: Sham feeding of defined fatty acid emulsions with peripherally restricted CB1 antagonists evidence_span: {"source_cache": "artifacts/thc-research/23463697.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079", "start_char": 0, "end_char": 1315, "text_sha256": "cf035f4613f2090d3eaa60f90857a2dd265f69435b63d470e3dbe82f2350a079"} [thc-p23463697] Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. (2013). https://pubmed.ncbi.nlm.nih.gov/23463697/ DOI: 10.1096/fj.13-227587
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.