Component
Alpha-tocopherol-13′-carboxychromanol
Long-chain terminal carboxylate metabolite of alpha-tocopherol, alpha-T-13′-COOH; not a tocotrienol metabolite.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Alpha-tocopherol-13′-carboxychromanol inhibited 5-LO product formation in activated human polymorphonuclear leukocytes with an IC50 of approximately 0.08 µM, compared with 0.27 µM for isolated recombinant human 5-LO.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Primary human PMNL and recombinant enzyme, Table 1
- exposure
- 10 min compound pretreatment at 37°C; PMNL in PBS pH 7.4, 1 mg/mL glucose and 1 mM CaCl2, stimulated with 2.5 µM A23187 and/or 20 µM arachidonic acid for 10 min; IC50 80 nM.
- limitations
- Potency cannot be equated with oral vitamin E dosing. The activated leukocyte IC50 differs greatly from parent alpha-tocopherol and from other laboratories’ assay results.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- The alpha-tocopherol metabolite reduced leukotriene-pathway enzyme output in isolated human immune cells.
- primary_references
- [pein2018] Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. (2018). https://pubmed.ncbi.nlm.nih.gov/30237488/ DOI: 10.1038/s41467-018-06158-5
- tissue_or_cell_type
- Isolated blood polymorphonuclear leukocytes and cell-free enzyme
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1011–1022
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Primary human PMNL and recombinant enzyme, Table 1 · source_derived_draft · unverified_draft
### e-sig-alpha-acid-leukocyte-lox Alpha-tocopherol-13′-carboxychromanol inhibited 5-LO product formation in activated human polymorphonuclear leukocytes with an IC50 of approximately 0.08 µM, compared with 0.27 µM for isolated recombinant human 5-LO. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The alpha-tocopherol metabolite reduced leukotriene-pathway enzyme output in isolated human immune cells. organism: Homo sapiens tissue_or_cell_type: Isolated blood polymorphonuclear leukocytes and cell-free enzyme experimental_model: Primary human PMNL and recombinant enzyme, Table 1 limitations: Potency cannot be equated with oral vitamin E dosing. The activated leukocyte IC50 differs greatly from parent alpha-tocopherol and from other laboratories’ assay results. exposure: 10 min compound pretreatment at 37°C; PMNL in PBS pH 7.4, 1 mg/mL glucose and 1 mM CaCl2, stimulated with 2.5 µM A23187 and/or 20 µM arachidonic acid for 10 min; IC50 80 nM. cross_nutrient: false [pein2018] Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. (2018). https://pubmed.ncbi.nlm.nih.gov/30237488/ DOI: 10.1038/s41467-018-06158-5
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.